Denver Broncos vs San Francisco 49ers Prediction, 10/4/2026 NFL Picks, Best Bets & Odds Week 4

Game: Denver Broncos vs San Francisco 49ers

Date: Sunday, October 4, 2026

Location: Levi's Stadium in Santa Clara, CA

TV: CBS

Odds-Point Spread: Broncos +3.0

Total-Over-Under: 46

Levi's Stadium is the location where the San Francisco 49ers (3-0) will try to beat the Denver Broncos (2-1) on Sunday. Denver opens this contest as 3-point dogs from oddsmakers. The total has been set at 46.

The Denver Broncos step on the gridiron holding a record of 2-1 over the course of this year. The last time they stepped on the football field, the Broncos took the field against the Los Angeles Rams and earned the victory with a final of 30-26. Bo Nix finished 17-34 with 186 yds through the air and 2 TDs. He had a QB rating of 73.9 and ended the contest with 1 pick. J.K. Dobbins led the offense in rushing for the Broncos with 17 carries for 49 yds (2.9 yds per attempt). Courtland Sutton had an average of 15.3 yds per catch by totaling 46 yards on 3 receptions. The Denver Broncos ended up rushing 25 times and amassed 78 yards, earning them an average of 3.1 yards per carry. At the end of the game, they had 59 plays which gave them 257 yards. Denver surrendered 30 pass completions on 55 tries for a total of 366 yards, and a completion rate of 54.5%. In the running game, the Broncos conceded 116 yards on 23 tries, which is an average of 5.0 yards per rush allowed.

Concerning getting the ball into the endzone, the squad residing in Denver are averaging 20.0 points per game. As a team, they're holding an average of 81.0 running yds putting them 31st in the league. The Broncos have recorded 825 total yards on the season. Denver has earned 29 1st downs, and they have committed 22 infractions for 143 yards. They have coughed up the ball 4 different times (3 picks and 1 fumble). If you look at notching touchdowns, Denver has produced 4 passing TD's and 2 touchdowns on the ground.

Concerning passing yards, the Broncos have yielded 711 total yards, putting them 25th in professional football. They have relinquished 237.0 yds per contest through the air, and are giving up a completion rate of 55.9%. Altogether, they have yielded 431 rushing yards through 3 contests over the course of this season. They have yielded 4 touchdowns via the pass, as well as 3 touchdowns to runners. Altogether, they are allowing 380.7 yds per contest, ranking this team at 29th in professional football. They are allowing teams to run for an average of 5.1 yards per rush on the ground and 143.7 rushing yards per outing so far this season. The Broncos are ranked 17th in football regarding their opponents scoring, conceding 23.3 PPG.

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The 49ers come into this matchup holding a record of 3-0 for this campaign. In their last game, the 49ers got the win with a final of 36-30 when they played the Arizona Cardinals. Christian McCaffrey ran the football 15 times for 75 yards, finishing the contest with 5.0 yds per attempt for San Francisco. George Kittle was a featured target for the 49ers, bringing in 6 passes for 82 yards (13.7 yds per catch). Brock Purdy (4 touchdowns) ended the contest with 297 yards on 15-27 through the air while his QB rating was 133.8. He didn't toss any picks and his avg yards per attempt was 11.0 yards. San Francisco gave up 27 rush attempts for 93 yds (3.4 yards per carry). The 49ers secondary gave up a completion percentage of 73.1%, relinquishing 272 yards on 38 out of 52 through the air. The 49ers finished the game with 437 yds and they ran 50 plays (8.7 yards per play). San Francisco ran the ball for 6.1 yards per carry, finishing with a total of 140 yds on 23 attempts.

With reference to putting points on the board, the 49ers are ranking 2nd in professional football, maintaining an average of 32.7 points per contest. So far this year, the 49ers have compiled 789 pass yds and average 263.0 pass yds per contest, ranking this team at 6th in professional football. They hold an average of 136.3 rushing yards per contest, and have run for 409 yards. The San Francisco 49ers hold an average of 399.3 yards per contest, which ranks them 5th in football. The San Francisco offense has conceded 168 yards by way of 16 infractions, ranking this team at 29th in professional football if you analyze giving up free yards. They have recorded 1 interception while relinquishing 1 fumble, and have been able to record 42 1st downs as a team.

They have surrendered 3 touchdowns through the air along with 207.3 pass yds per contest, ranking this team at 14th in professional football. San Francisco has allowed a total of 317 rush yards (105.7 yards per game), plus 2 touchdowns via the rush over the course of the season. The defense has amassed 2 turnovers (1 fumble and 1 interception) over the course of the season. Altogether, they have yielded 50 points in total. The 49ers defense has participated in 194 plays from the line of scrimmage, ranking this team at 25th in pro football. The 49ers are allowing 16.7 PPG, ranking this team at 3rd in professional football.

Who will win tonight's Broncos-49ers NFL game against the spread?

Tony's Pick: Take the Broncos +3.0

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