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San Francisco 49ers vs Seattle Seahawks Prediction, 1/17/2026 NFL Picks, Best Bets & Odds
by Guy Bruhn - 1/14/2026

The San Francisco 49ers take on the Seattle Seahawks at Lumen Field in Seattle, WA. San Francisco is 7.5-point underdogs from Vegas oddsmakers. This report includes betting predictions and our expert NFL picks for todays game. Read More >>

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San Francisco 49ers vs Philadelphia Eagles Prediction, 1/11/2026 NFL Picks, Best Bets & Odds
by Parlays Pundit - 1/6/2026

The San Francisco 49ers (12-5) are traveling to Lincoln Financial Field on Sunday where they will meet the Philadelphia Eagles (11-6) in an NFC Wild Card game. San Francisco opens this matchup as 4.5-point dogs from oddsmakers. The betting total comes in at 45. We have included an expert NFL pick and parlay for todays game against the spread. Read More >>

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Seattle Seahawks vs San Francisco 49ers Prediction, 1/3/2026 NFL Picks, Best Bets & Odds Week 18
by Tony Sink - 1/1/2026

Levi's Stadium is the place where the San Francisco 49ers (12-4) will attempt to beat the Seattle Seahawks (13-3) on Sunday. San Francisco opens as 1.5-point dogs. The total is 47.5. This report includes betting odds and our expert football picks for todays game. Read More >>

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Chicago Bears vs San Francisco 49ers Prediction, 12/28/2025 NFL Picks, Best Bets & Odds Week 17
by Tony Sink - 12/25/2025

The San Francisco 49ers (11-4) will go up against the Chicago Bears (11-4) at Levi's Stadium on Sunday. Chicago opens as 3-point underdogs from oddsmakers. The betting total comes in at 52.5. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup. Read More >>

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San Francisco 49ers vs Indianapolis Colts Prediction, 12/22/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday. Indianapolis is 6-point dogs from Vegas oddsmakers. The total is set at 46.5. This matchup report includes odds, betting predictions and a free pick against the spread. Read More >>

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Tennessee Titans vs San Francisco 49ers Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15
by Tony Sink - 12/11/2025

The Tennessee Titans (2-11) are on their way to Levi's Stadium on Sunday where they will attempt to beat the San Francisco 49ers (9-4). Tennessee opens this matchup as 12.5-point dogs from oddsmakers. The betting total comes in at 44.5. This report includes betting odds and our expert football picks for todays game. Read More >>

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San Francisco 49ers vs Cleveland Browns Prediction, 11/30/2025 NFL Picks, Best Bets & Odds Week 13
by Guy Bruhn - 11/25/2025

The San Francisco 49ers (8-4) are on their way to Huntington Bank Field on Sunday where they will try to beat the Cleveland Browns (3-8). San Francisco opens this contest as 5-point favorites from Vegas oddsmakers. The over-under comes in at 38. This matchup report includes Vegas odds and a free NFL prediction for tonight. Read More >>

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Carolina Panthers vs San Francisco 49ers Prediction, 11/24/2025 NFL Picks, Best Bets & Odds Week 12
by Guy Bruhn - 11/19/2025

The Carolina Panthers (6-5) are headed to Levi's Stadium on Monday where they will play the San Francisco 49ers (7-4). San Francisco opens this matchup as 7-point favorites from Vegas oddsmakers. The betting total comes in at 48.5. This matchup report includes betting lines and our NFL pick of the day for this game. Read More >>

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San Francisco 49ers vs Arizona Cardinals Prediction, 11/16/2025 NFL Picks, Best Bets & Odds Week 11
by Guy Bruhn - 11/12/2025

State Farm Stadium is the place where the Arizona Cardinals (3-6) will try to defeat the San Francisco 49ers (6-4) on Sunday. Arizona opens this contest as 2.5-point underdogs from oddsmakers. The total is set at 49. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Los Angeles Rams vs San Francisco 49ers Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10
by Guy Bruhn - 11/5/2025

The San Francisco 49ers (6-3) host the Los Angeles Rams (6-2) at Levi's Stadium on Sunday. Los Angeles opens this contest as 4-point favorites from Vegas oddsmakers. The betting total is set at 49.5. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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San Francisco 49ers vs New York Giants Prediction, 11/2/2025 NFL Picks, Best Bets & Odds Week 9
by Tony Sink - 10/28/2025

MetLife Stadium is where the New York Giants (2-6) will attempt to defeat the San Francisco 49ers (5-3) on Sunday. San Francisco opens this game as 2.5-point favorites from Vegas oddsmakers. The total has been set at 48.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner. Read More >>

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San Francisco 49ers vs Houston Texans Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8
by Guy Bruhn - 10/22/2025

NRG Stadium is where the Houston Texans (2-4) will try to defeat the San Francisco 49ers (5-2) on Sunday. Houston is 1.5-point favorites. The total is 41.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game. Read More >>

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Atlanta Falcons vs San Francisco 49ers Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7
by Tony Sink - 10/14/2025

The San Francisco 49ers (4-2) will try to defeat the Atlanta Falcons (3-2) at Levi's Stadium on Sunday. Atlanta opens this contest as 2-point underdogs. The total is 47.5. This report includes betting odds and our expert football picks for todays game. Read More >>

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San Francisco 49ers vs Tampa Bay Buccaneers Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6
by Josh Schonwald - 10/7/2025

The San Francisco 49ers (4-1) are on their way to Raymond James Stadium on Sunday where they will play the Tampa Bay Buccaneers (4-1). San Francisco is 3-point underdogs from oddsmakers. The total comes in at 47.5. This games report has current odds, betting predictions, and free picks against the spread. Read More >>

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San Francisco 49ers vs Los Angeles Rams Prediction, 10/2/2025 NFL Picks, Best Bets & Odds Week 5
by Tony Sink - 9/30/2025

The San Francisco 49ers (3-1) are headed to SoFi Stadium on Thursday where they will try to defeat the Los Angeles Rams (3-1). Los Angeles opens this contest as 5.5-point favorites from Vegas oddsmakers. The total has been set at 47. This matchup report includes NFL odds, predictions, and a free pick against the spread. Read More >>

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Jacksonville Jaguars vs San Francisco 49ers Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4
by Guy Bruhn - 9/23/2025

The Jacksonville Jaguars (2-1) are headed to Levi's Stadium on Sunday where they will compete against the San Francisco 49ers (3-0). San Francisco is 3.5-point favorites. The total is set at 47. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Arizona Cardinals vs San Francisco 49ers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

Levi's Stadium is the place where the San Francisco 49ers (2-0) will attempt to beat the Arizona Cardinals (2-0) on Sunday. Arizona opens this game as 1.5-point underdogs from oddsmakers. The total is set at 43.5. This matchup report includes betting lines and our NFL pick of the day for this game. Read More >>

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San Francisco 49ers vs New Orleans Saints Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2
by Tony Sink - 9/9/2025

Caesars Superdome is the location where the New Orleans Saints (0-1) will meet the San Francisco 49ers (1-0) on Sunday. New Orleans is 4.5-point underdogs from oddsmakers. The over-under is 42.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner. Read More >>

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San Francisco 49ers vs Seattle Seahawks Prediction, 9/7/2025 NFL Picks, Best Bets & Odds Week 1
by Josh Schonwald - 9/3/2025

The San Francisco 49ers (6-11 last season) are on their way to Lumen Field on Sunday where they will attempt to defeat the Seattle Seahawks (10-7 last year). Seattle opens as 2.5-point dogs. The total is set at 43.5. This matchup report includes odds, NFL betting predictions and a free pick against the spread. Read More >>

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San Francisco 49ers vs Arizona Cardinals Prediction, 1/5/2025 NFL Picks, Best Bets & Odds Week 18
by Tony Sink - 12/31/2024

The Arizona Cardinals (7-9) host the San Francisco 49ers (6-9) at State Farm Stadium on Sunday. San Francisco is 2.0-point favorites. The total comes in at 47. This matchup report includes NFL odds, predictions, and a free pick against the spread. Read More >>

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