San Francisco 49ers vs Seattle Seahawks Prediction, 10/11/2026 NFL Picks, Best Bets & Odds Week 5

Game: San Francisco 49ers vs Seattle Seahawks

Date: Sunday, October 11, 2026

Location: Lumen Field in Seattle, WA

TV: FOX

Odds-Point Spread: 49ers +3.0

Total-Over-Under: 47

The San Francisco 49ers (4-0) are headed to Lumen Field on Sunday where they will meet the Seattle Seahawks (3-1). Seattle opens this matchup as 3-point favorites. The total is set at 47.

The San Francisco 49ers come into this game holding a record of 4-0 this year. When they last took the field, the 49ers faced off with the Denver Broncos and earned the victory with a final of 24-14. Brock Purdy finished 19-30 with 218 yds passing and 2 touchdowns. He had a quarterback rating of 107.4 and finished the game without throwing an interception. Mike Evans held an average of 15.2 yds per reception by earning 76 yds on 5 receptions. Christian McCaffrey was the leader on the ground for the 49ers with 15 carries for 52 yards (3.5 yards per carry). In all, they tallied 65 plays for 358 yds. The San Francisco 49ers ran the rock 35 times and had 140 yds, earning them an average of 4.0 yds per attempt. In the running game, the 49ers gave up 82 yards on 22 attempts, which calculates to 3.7 yds per run allowed. San Francisco relinquished 25 pass completions on 42 attempts for 214 yds, and a completion rate of 59.5%.

The 49ers have produced 1,556 yards so far this year. San Francisco has accumulated 50 1st downs offensively, and they have been hurt by 17 infractions for 173 yards. When talking about getting the ball into the endzone, San Francisco has accumulated 11 touchdowns via the pass and 5 rushing TD's. They have given the ball to the opposition 2 times (1 interception and 1 fumble). Collectively, they average 137.3 rushing yds which has them ranking 6th in pro football. If you analyze getting in the endzone, the 49ers are averaging 30.5 points per outing.

If you look at yards via the pass, the 49ers have surrendered 836 yds, putting them 11th in football. They have granted 209.0 total yards per contest through the air, and are surrendering a completion% of 64.8%. Overall, they have yielded 399 yards on the ground through 4 matchups on the campaign. They have given up 4 touchdowns via the pass, plus 2 touchdowns to runners. All in all, they are allowing 308.8 total yards per contest, which has them ranking 7th in pro football. They are allowing 3.7 yds per rushing attempt and 99.8 running yards per contest this year. The 49ers currently rank 3rd in the NFL regarding their defensive abilities, surrendering 16.0 points per contest.

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The Seahawks step on the gridiron with a record of 3-1 on the season. In their last game, the Seahawks walked away with a victory by a final of 30-23 against the Los Angeles Chargers. Sam Darnold (2 TDs) finished the game with 168 yards on 13-22 passing while his QB rate was 94.5. He tossed 1 interception and his average yds per pass attempt was 7.6 yards. Emanuel Wilson ran the ball 21 times for 81 yds, finishing the game with 3.9 yards per carry for Seattle. Jaxon Smith-Njigba was a featured target for the Seahawks, grabbing 5 throws for 76 yards (15.2 yards per reception). Seattle rushed for 4.2 yards per carry, finishing the contest with 138 yds on 33 attempts. The Seahawks finished the contest with a total of 286 yards while they ran 55 plays (5.2 yds per play). The Seahawks secondary conceded a completion rate of 59.4%, surrendering 154 yards on 19 out of 32 through the air. Seattle allowed 32 run attempts for 147 yds (4.6 yds per rush).

The Seattle Seahawks have an average of 347.3 total yards per contest, which has them ranked 13th in pro football. They maintain an average of 110.3 running yards per contest, and have carried the ball for 441 total yards. They have allowed 3 interceptions while conceding 2 lost fumbles, and have been able to record 52 1st downs as a unit. The Seattle offense has surrendered 327 total yards by way of 35 penalty flags, giving them a rank of 8th in the league concerning making mistakes. So far this season, the Seahawks have a total of 948 passing yards and hold an average of 237.0 passing yards per game, which has them ranked 14th in pro football. When analyzing putting points on the board, the Seahawks currently rank 10th in the NFL, averaging 26.3 points per contest.

They have given up 6 touchdowns via the pass plus 144.8 pass yards per game, giving them a rank of 1st in the league. Seattle has granted a total of 408 running yards (102.0 total yards per contest), in addition to 1 touchdown by way of the ground game this year. The D has earned 8 turnovers (2 fumbles forced and 6 INTs) on the campaign. Overall, they have yielded 73 pts. The Seahawks defense has taken the field for 247 plays, which has them ranked 16th in the NFL. The Seahawks are yielding 18.3 PPG, putting them 5th in football.

Who will win tonight's 49ers-Seahawks NFL game against the spread?

Tony's Pick: Take the 49ers +3.0

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