San Francisco 49ers vs Seattle Seahawks Prediction, 1/17/2026 NFL Picks, Best Bets & Odds

Game: San Francisco 49ers vs Seattle Seahawks

Date: Saturday, January 17, 2026

Location: Lumen Field in Seattle, WA

TV: FOX

Odds-Point Spread: Seahawks (-7.5)

Total-Over-Under: 44.5

The San Francisco 49ers (12-5) are traveling to Lumen Field on Sunday where they will take on the Seattle Seahawks (14-3) in an NFC Divisional Playoff game. San Francisco opens this contest as 7.5-point dogs. The over-under is set at 44.5.

The San Francisco 49ers head into this matchup 12-5 on the campaign. In their last game, the 49ers stepped onto the field against the Philadelphia Eagles and walked away with a win by a score of 23-19. Brock Purdy went 18-31 with 262 yards passing and 2 touchdowns. He had a QB rate of 80.3 and walked away from the game with 2 interceptions. Christian McCaffrey had an average of 11.0 yards per reception by accounting for 66 yds on 6 catches. Christian McCaffrey led the offense in rushing for the 49ers with 15 carries for 48 yards (3.2 yards per carry). When all was said and done, they had 57 plays which gave them a total of 361 yds. The San Francisco 49ers ended up rushing 25 different times and compiled 75 yds, earning them an average of 3.0 yards per tote. In the running game, the 49ers gave up 140 yds on 36 attempts, which is an average of 3.9 yds per rush surrendered. San Francisco conceded 20 completions on 35 attempts for a total of 167 yds, and a completion rate of 57.1%.

The 49ers have recorded 5,974 yards over the course of this year. San Francisco has attained 237 first downs as an offense, and they have been flagged for 83 penalties for 651 total yards. Regarding scoring touchdowns, San Francisco has racked up 33 touchdowns via the pass and 15 touchdowns via the run. They have surrendered the ball 22 different times (16 interceptions and 6 lost fumbles). As a team, they are sitting at 106.9 rushing yards which is 24th in professional football. If you examine scoring points, the NFC West members have an average of 25.7 points per contest.

The 49ers rank 13th in pro football if you analyze their defensive abilities, surrendering 21.8 points per outing. The opposition is running for 4.3 yards per rush and 107.8 rushing yards per contest on the year. If you examine passing yds, the 49ers have granted 3,951 yds, ranking this team at 25th in the league. They have surrendered 232.4 total yards per contest by way of the pass, and are relinquishing a completion% of 68.2%. On the whole, they are granting 340.2 yds per contest, which has them ranking 20th in professional football. They have surrendered 29 touchdowns by way of the pass, plus 13 touchdowns via the rush. On the whole, they have allowed 1,833 rushing yards through 17 outings on the campaign.

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The Seahawks come into this matchup holding a record of 14-3 over the course of this year. The last time they took the field, the Seahawks took home the win by a final score of 13-3 against the San Francisco 49ers. Zach Charbonnet ran the football 17 times for 74 yds, finishing the game with 4.4 yds per carry for Seattle. Jaxon Smith-Njigba was featured in the passing game for the Seahawks, bringing in 6 footballs for 84 yds (14.0 yds per catch). Sam Darnold finished the game with 198 yds on 20-26 through the air while his quarterback rate was 97.9. He didn't toss any interceptions and his average yards per pass attempt was 7.6 yards. Seattle surrendered 12 rushing attempts for 53 yards (4.4 yds per rush). The Seahawks secondary conceded a completion rate of 70.4%, surrendering 120 yds on 19 out of 27 passing. The Seahawks finished the game with 361 yards and they ran 65 plays (5.6 yds per play). Seattle ran the ball for 4.6 yards per tote, finishing with a total of 180 yards on 39 carries.

The Seattle Seahawks have an average of 351.4 yards per contest, giving them a rank of 8th in the league. They hold an average of 123.3 rush yds per outing, and have rushed for 2,096 yards. They have tossed 15 picks while granting 13 fumbles, and have recorded 179 first downs as a team. The Seattle offense has surrendered 793 yards on 100 violations, which ranks them 25th in football in terms of giving up free yards. So far this year, the Seahawks have thrown for a total of 3,877 yards through the air and average 228.1 yards through the air per contest, which is 8th in professional football. When examining their ability to score points, the Seahawks are sitting 3rd in the NFL, scoring 28.4 points per contest.

They have allowed 20 touchdowns via the pass along with 193.9 passing yards per outing, which ranks them 10th in football. Seattle has conceded a total of 1,563 rushing yds (91.9 yds per contest), in addition to 9 touchdowns on the ground this year. Their defense has accrued 25 takeaways (7 fumbles forced and 18 picks) on the campaign. Overall, they have yielded 292 pts. The Seahawks defense has taken part in 1,065 plays from the line of scrimmage, which has them ranking 23rd in professional football. The Seahawks are surrendering 17.2 points per game, which is 1st in professional football.

Who will win tonight's 49ers-Seahawks NFL game against the spread?

Guy's Pick: Take the Seahawks -7.5

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