San Francisco 49ers vs Atlanta Falcons Prediction, 10/25/2026 NFL Picks, Best Bets & Odds Week 7

Game: San Francisco 49ers vs Atlanta Falcons

Date: Sunday, October 25, 2026

Location: Mercedes-Benz Stadium in Atlanta, GA

TV: FOX

Odds-Point Spread: 49ers -3.0

Total-Over-Under: 48.5

The Atlanta Falcons (2-4) will take on the San Francisco 49ers (6-0) at Mercedes-Benz Stadium on Sunday. San Francisco is 3-point favorites. The over-under is set at 48.5.

The San Francisco 49ers head into this game 6-0 for the year. In their last contest, the 49ers went up against the Washington Commanders and notched a win by a score of 23-17. Brock Purdy went 21-29 with 264 yds through the air and 1 TD. He had a QB rating of 111.9 and finished the contest without throwing a pick. Mike Evans left with an average of 31.3 yards per catch by accounting for 94 yards on 3 catches. Christian McCaffrey was the best rusher for the 49ers with 16 totes for 64 yards (4.0 yds per carry). In all, they tallied 58 plays which gave them 375 yards. The San Francisco 49ers rushed the ball a total of 29 times and accumulated 126 yards, which came out to an average of 4.3 yds per carry. Against the run, the 49ers conceded 53 yards on 17 tries, which is an average of 3.1 yds per run allowed. San Francisco surrendered 29 pass completions on 40 tries for 261 yards, and a completion rate of 72.5%.

When it comes to scoring points, the squad who plays in San Francisco are averaging 29.5 points per game. Collectively, they average 128.2 rushing yards ranking this team at 7th in pro football. The 49ers have racked up 2,200 yards for this campaign. San Francisco has collected 68 1st downs as an offense, and they have been called for 36 penalties for 331 yards. They have turned the football over 6 times (2 INTs and 4 lost fumbles). When it comes to scoring, San Francisco has produced 14 passing touchdowns and 8 rushing TD's.

When it comes to yards via the pass, the 49ers have granted 1,259 yards, which has them ranked 16th in football. They have allowed 209.8 yds per contest by way of the pass, and are conceding a completion rate of 65.9%. All in all, they have surrendered 541 yards via the ground game in 6 outings for this campaign. They have granted 7 touchdowns by way of the pass, as well as 3 touchdowns to rushers. In total, they are granting 300.0 yds per contest, which ranks 5th in pro football. Opposing teams are running for an average of 3.6 yds per attempt on the ground and 90.2 rushing yds per game for the year. The 49ers currently rank 4th in pro football when examining the opposition scoring, relinquishing 18.3 PPG.

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The Falcons step on the gridiron with a record of 2-4 for this campaign. In their last game, the Falcons went home defeated by a final of 31-23 against the Chicago Bears. Michael Penix (3 touchdowns) ended the contest with 225 yds on 19-33 passing while his quarterback rate was 108.8. He kept the ball away from the defense with no picks and his average yards per pass attempt was 6.8 yards. Jahan Dotson was featured in the passing game for the Falcons, snagging 3 passes for 87 yards (29.0 yds per reception). Bijan Robinson ran the football 9 times for 61 yards, finishing the contest with 6.8 yds per carry for Atlanta. The Falcons finished the contest with 257 yards while running 45 plays (5.7 yards per play). Atlanta ran the ball for 5.3 yds per carry, finishing with 63 yards on 12 attempts. Atlanta conceded 33 rush attempts for 98 yards (3.0 yds per rush). The Falcons passing defense gave up a completion percentage of 83.3%, surrendering 270 yards on 30 for 36 passing.

When examining this team's ability to score points, the Falcons currently rank 16th in football, with 23.7 points per outing. So far this season, the Falcons have a total of 1,169 passing yds and are averaging 194.8 passing yds per contest, ranking them 24th in football. They have an average of 149.5 running yards per game, and have rushed for 897 yards. The Atlanta Falcons average 344.3 yards per contest, ranking them 12th in football. The Atlanta offense has allowed 386 yds by way of 40 penalties, putting them 22nd in pro football when examining giving up free yards. They have allowed 7 INTs while giving up 5 lost fumbles, and have earned 54 first downs as a unit.

They have allowed 10 touchdowns via the pass plus 252.0 pass yards per contest, which is 28th in professional football. Atlanta has allowed a total of 499 rushing yards (83.2 yds per game), and 6 touchdowns by way of the ground game for this campaign. The D has accrued 5 takeaways (4 fumbles forced and 1 interception) over the course of this season. Altogether, they have relinquished 153 points in total. The Falcons defense has taken the field for 400 plays, ranking this team at 29th in pro football. The Falcons are giving up 25.5 points per game, which is 23rd in professional football.

Who will win tonight's 49ers-Falcons NFL game against the spread?

Josh's Pick: Take the 49ers -3.0

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