Miami Dolphins vs San Francisco 49ers Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2

Game: Miami Dolphins vs San Francisco 49ers

Date: Sunday, September 20, 2026

Location: Levi's Stadium in Santa Clara, CA

TV: FOX

Odds-Point Spread: 49ers -13.5

Total-Over-Under: 45.5

The Miami Dolphins (0-1) are traveling to Levi's Stadium on Sunday where they will compete against the San Francisco 49ers (1-0). Miami opens as 13.5-point underdogs from oddsmakers. The betting total comes in at 45.5.

The Miami Dolphins head into this matchup 0-1 so far this season. When they last took the field, the Dolphins faced off with the Las Vegas Raiders and walked away from this one with a loss by a score of 27-13. Malik Willis connected on 15-27 with 220 yds passing. He had a QB rating of 66.9 and finished the contest with 1 pick. De'Von Achane was the best rusher for the Dolphins with 11 totes for 36 yds (3.3 yds per attempt). Caleb Douglas averaged 18.8 yards per reception by accumulating 94 yards on 5 catches. The Miami Dolphins ran the football 18 times and totaled 74 yds, which is an average of 4.1 yards per tote. For the game, they had 45 plays which totaled 259 yards. Miami surrendered 21 pass completions on 30 tries for a total of 160 yards, and a completion rate of 70.0%. On the ground, the Dolphins gave up 130 yds on 37 attempts, which calculates to 3.5 yds per rush allowed.

The Dolphins have accumulated 259 yards over the course of this year. Miami currently has 7 first downs as an offense, and they have been flagged for 8 infractions for 61 total yards. When analyzing getting the ball in the endzone, Miami has compiled 1 rushing touchdown. They have surrendered the football 2 different times (1 interception and 1 fumble). As a unit, they maintain an average of 74.0 rush yards putting them 27th in professional football. Concerning putting points on the board, the team residing in Miami are sitting at 13.0 points per game.

If you're looking at pass yds, the Dolphins have relinquished 160 yards, which has them ranked 6th in professional football. They have surrendered 160.0 total yards per outing via the pass, and are allowing a completion percentage of 70.0%. Altogether, they have allowed 130 running yards through 1 game so far this year. They have given up 3 touchdowns through the air. Altogether, they are relinquishing 290.0 total yards per contest, which is good for 15th in the league. They are giving up 3.5 yards per attempt on the ground and 130.0 rush yards per contest over the course of this year. The Dolphins currently sit 18th in the NFL when you look at their defensive prowess, allowing 27.0 PPG.

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The 49ers head into this matchup 1-0 so far this year. In their last contest, the 49ers got the win with a final of 27-7 against the Los Angeles Rams. Kaelon Black ran the football 14 times for 65 yds, finishing the game with 4.6 yds per carry for San Francisco. Mike Evans was the best receiver for the 49ers, snagging 6 balls for 49 yards (8.2 yards per catch). Brock Purdy (3 TDs) ended the contest with 205 yds on 25-34 passing while his QB rating was 105.6. He tossed 1 pick and his average yds per pass attempt was 6.0 yds. San Francisco relinquished 29 attempts on the ground for 122 yds (4.2 yards per rush). The 49ers secondary gave up a completion percentage of 60.7%, surrendering 168 yds on 17 out of 28 passing. The 49ers finished with 379 yds and they ran 64 plays (5.9 yards per play). San Francisco rushed the football for 5.8 yards per attempt, finishing the contest with 174 yards on 30 attempts.

When talking about the points being put on the board, the 49ers currently sit 14th in pro football, by tallying 27.0 points per outing. Over the course of this season, the 49ers have a total of 205 passing yards. They average 174.0 rushing yards per outing. The San Francisco 49ers maintain an average of 379.0 yds per contest, which is 11th in pro football. The San Francisco offense has yielded 21 yds on 2 penalty flags, ranking them 32nd in pro football if you're looking at hurting your team. They have allowed 1 interception and have been able to obtain 12 1st downs.

They have allowed no TD's via the pass along with 168.0 pass yds per contest, which ranks 8th in pro football. San Francisco has yielded a total of 122 rush yds. The D has accrued 2 takeaways (1 fumble and 1 interception) this year. All in all, they have relinquished 7 pts. The 49ers defense has been on the field for 57 plays, which is 13th in pro football. The 49ers are conceding 7.0 points per outing, which ranks them at 1st in the league.

Who will win tonight's Dolphins-49ers NFL game against the spread?

Guy's Pick: Take the 49ers -13.5

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