San Francisco 49ers vs Dallas Cowboys Prediction, 11/15/2026 NFL Picks, Best Bets & Odds Week 10

Game: San Francisco 49ers vs Dallas Cowboys

Date: Sunday, November 15, 2026

Location: AT&T Stadium in Arlington, TX

TV: FOX

Odds-Point Spread: Cowboys +4.0

Total-Over-Under: 55.5

The Dallas Cowboys (4-5) are hosting the San Francisco 49ers (7-1) at AT&T Stadium on Sunday. Dallas is 4-point underdogs from Vegas oddsmakers. The total has been set at 55.5.

The San Francisco 49ers step on the gridiron 7-1 over the course of the season. The last time they took the field, the 49ers played the Las Vegas Raiders and earned the victory with a final of 38-17. Christian McCaffrey led the offense in rushing for the 49ers with 18 carries for 68 yards (3.8 yards per carry). George Kittle averaged 14.5 yds per reception by earning 58 yards on 4 receptions. Brock Purdy connected on 17-25 with 232 yards through the air and 2 touchdowns. He had a quarterback rate of 107.4 and walked away from the contest with 1 pick. In the running game, the 49ers gave up 24 yards on 15 attempts, which is 1.6 yds per run allowed. San Francisco allowed 22 completions on 32 attempts for 216 yds, and a completion rate of 68.8%. Overall, they tallied 68 plays which totaled 414 yds. The San Francisco 49ers ran the ball a total of 43 different times and accumulated 190 yds, which is an average of 4.4 yards per tote.

In terms of getting in the endzone, the team representing San Francisco have an average of 29.4 PPG. Offensively, they hold an average of 135.3 running yards which has them sitting 7th in the league. The 49ers have compiled 3,014 total yards for this campaign. San Francisco has racked up 97 1st downs as a team, and they have been flagged for 50 infractions for 445 total yards. They have coughed up the ball 11 different times (5 interceptions and 6 fumbles lost). Regarding notching touchdowns, San Francisco has tallied 17 touchdowns via the pass and 12 touchdowns via the ground.

Regarding yards via the pass, the 49ers have allowed 1,688 yds, which is good for 5th in the league. They have relinquished 211.0 total yards per contest by way of the pass, and are conceding a completion percentage of 67.1%. Altogether, they have relinquished 647 rushing yards through 8 outings for the season. They have given up 11 touchdowns through the air, and 4 touchdowns via the rush. On the whole, they are yielding 291.9 yards per game, which has them sitting 3rd in the league. They are giving up an average of 3.3 yards per running attempt and 80.9 running yards per game over the course of the season. The 49ers are 6th in the NFL if you look at their defensive prowess, conceding 19.5 points per game.

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The Cowboys come into this matchup holding a record of 4-5 for this campaign. In their last game, the Cowboys got the win with a final of 27-23 against the Indianapolis Colts. Dak Prescott (2 TDs) walked away from the contest with 335 yards on 21-34 through the air while his quarterback rating was 114.2. He didn't throw any picks and his average yards per pass attempt was 9.9 yds. Javonte Williams carried the rock 20 times for 101 yards, finishing the contest with 5.1 yds per carry for Dallas. CeeDee Lamb was the best receiver for the Cowboys, catching 10 throws for 195 yards (19.5 yds per reception). Dallas rushed for 5.3 yds per carry, finishing with a total of 179 yds on 34 carries. The Cowboys finished the contest with 508 yards while they ran 68 plays (7.5 yards per play). The Cowboys secondary conceded a completion rate of 58.8%, surrendering 166 yds on 20 for 34 passing. Dallas conceded 23 rushing attempts for 105 yds (4.6 yards per carry).

When you look at their scoring prowess, the Cowboys are 6th in the NFL, by scoring 27.3 points per game. In this season, the Cowboys have a total of 2,312 pass yards and are sitting at 256.9 pass yards per game, which has them sitting 6th in the league. They average 103.6 rush yds per outing, and have run for 932 yds. The Dallas Cowboys maintain an average of 360.4 total yards per game, which is 10th in football. The Dallas offense has granted 667 yards on 74 violations, which has them sitting 2nd in the league when examining hurting your team. They have thrown 5 INTs while conceding 4 lost fumbles, and have obtained 119 first downs as an offense.

The Cowboys are granting 26.2 PPG, putting them 25th in pro football. They have conceded 16 touchdowns by way of the pass in addition to 225.2 pass yards per game, which has them sitting 18th in the league. Dallas has relinquished a total of 1,327 rush yds (147.4 yards per contest), and 11 touchdowns via the rush over the course of this season. The Cowboys defense has taken part in 579 plays from the line of scrimmage, which has them sitting 28th in the league. The D has a total of 8 takeaways (4 fumbles forced and 4 picks) so far this year. Altogether, they have surrendered 236 pts.

Who will win tonight's 49ers-Cowboys NFL game against the spread?

Josh's Pick: Take the Cowboys +4.0

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