San Francisco 49ers vs Los Angeles Rams Prediction, 9/10/2026 NFL Picks, Best Bets & Odds Week 1

Game: San Francisco 49ers vs Los Angeles Rams

Date: Thursday, September 10, 2026

Location: Melbourne Cricket Ground in Melbourne, Australia

TV: Netflix

Odds-Point Spread: Rams -3.5

Total-Over-Under: 48

The San Francisco 49ers (12-5 last year) are on their way to Melbourne Cricket Ground on Thursday where they will meet the Los Angeles Rams (12-5 last season). San Francisco is 3.5-point dogs. The over-under is set at 48.

The San Francisco 49ers wrapped up their year having amassed a 12-5 mark. When they last stepped on the football field, the 49ers faced the Seattle Seahawks and went home with a loss by a final score of 41-6. Brock Purdy was the best rusher for the 49ers with 5 totes for 37 yds (7.4 yds per attempt). Jake Tonges averaged 11.8 yds per reception by totaling 59 yds on 5 receptions. Brock Purdy finished 15-27 with 140 yards passing. He had a quarterback rating of 54.6 and finished the contest with 1 pick. Against the run, the 49ers gave up 175 yards on 33 attempts, which is an average of 5.3 yards per run allowed. San Francisco allowed 12 pass completions on 17 tries for 106 yards, and a completion rate of 70.6%. In the game, they ran 58 plays which converted into 236 yds. The San Francisco 49ers ended up rushing 27 times and totaled 108 yards, which earned them an average of 4.0 yds per carry.

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When examining getting the ball in the endzone, the 49ers held an average of 25.7 points per game. Offensively, they were averaging 106.9 rushing yds, ranking them 24th in the NFL. The 49ers collected 5,974 yards for last season. San Francisco had a total of 237 first downs offensively, and they were called for 83 infractions for 651 yards. They gave the ball to the opposition 22 times (16 picks and 6 lost fumbles). San Francisco compiled 33 touchdowns through the air and 15 ground TD's.

If you're looking at passing yds, the 49ers surrendered 3,951 yards which had them ranked 25th in the NFL. They allowed 232.4 yards per contest by way of the pass, and conceded a completion rate of 68.2%. Overall, they surrendered 1,833 running yards through 17 contests last season. They yielded 29 passing touchdowns, as well as 13 via the ground game. Altogether, they allowed 340.2 per contest, which had them ranking 20th in football. They allowed teams to run for an average of 4.3 yds per running attempt and 107.8 rushing yds per game for last year. The 49ers were ranked 13th in the NFL when analyzing opponents scoring, surrendering 21.8 points per contest.

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The Rams wrapped up their season having a 12-5 mark. The last time they took the field, the Rams went home defeated by a final of 31-27 when they played the Seattle Seahawks. Blake Corum carried the football 9 times for 55 yards, ending the contest with 6.1 yds per attempt for Los Angeles. Puka Nacua was the leading receiver for the Rams, hauling in 9 throws for 165 yards (18.3 yards per catch). Matthew Stafford (3 TDs) finished the contest with 374 yards on 22-35 through the air while his quarterback rate was 127.6. He didn't throw any interceptions and his average yards per pass attempt was 10.7 yds. Los Angeles gave up 26 attempts on the ground for 75 yards (2.9 yards per carry). The Rams secondary conceded a completion rate of 69.4%, relinquishing 321 yds on 25 out of 36 through the air. The Rams finished the game with 479 yds while running 57 plays (8.4 yards per play). Los Angeles ran the ball for 5.2 yards per attempt, finishing with 114 yards on 22 attempts.

When talking about the points being put on the board, the Rams sat 1st in football, averaging 30.5 points per game. In the previous season, the Rams earned 4,557 passing yards and averaged 268.1 passing yards per outing, which had them ranking 1st in professional football. They held an average of 126.6 rush yards per contest, and carried the football for 2,152 yards. The Los Angeles Rams held an average of 394.6 yds per game, which had them ranking 1st in pro football. The Los Angeles offense allowed 573 total yards by way of 75 violations, which was 32nd in football concerning making mistakes. They yielded 8 INTs while surrendering 7 fumbles, and accrued 236 first downs.

The Rams allowed 20.4 points per game, which ranked them at 10th in pro football. They granted 26 touchdowns through the air and 216.7 yards through the air per outing, ranking them 19th in the NFL. Los Angeles relinquished a total of 1,884 rushing yds (110.8 yds per outing), and 8 touchdowns via the rush for last year. The Rams defense participated in 1,072 plays from scrimmage, which was 24th in football. The D had a total of 26 takeaways (10 fumbles forced and 16 INTs) for last year. Altogether, they granted 346 points in total.

Who will win tonight's 49ers-Rams NFL game against the spread?

Guy's Pick: Take the Rams -3.5

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