Houston Texans vs Indianapolis Colts Prediction, 9/27/2026 NFL Picks, Best Bets & Odds Week 3

Game: Houston Texans vs Indianapolis Colts

Date: Sunday, September 27, 2026

Location: Lucas Oil Stadium in Indianapolis, IN

TV: CBS

Odds-Point Spread: Texans -2.5

Total-Over-Under: 43

The Indianapolis Colts (0-2) are welcoming the Houston Texans (0-2) at Lucas Oil Stadium on Sunday. Indianapolis opens this contest as 2.5-point underdogs from Vegas oddsmakers. The betting total is set at 43.

The Houston Texans come into this game holding a record of 0-2 over the course of the season. The last time they took the field, the Texans took the field against the Cincinnati Bengals and walked away from this one with a loss by a score of 20-6. C.J. Stroud went 30-55 with 353 yards passing. He had a quarterback rate of 74.3 and finished the contest without throwing a pick. C.J. Stroud was the best rusher for the Texans with 3 carries for 29 yds (9.7 yds per carry). Dalton Schultz held an average of 11.7 yards per catch by accumulating 140 yards on 12 catches. The Houston Texans ended up running the ball 18 times and had 60 yds, which came out to an average of 3.3 yds per attempt. On the day, they ran 74 plays which converted into 374 yds. Houston conceded 20 completions on 31 attempts for 182 yards, and a completion percentage of 64.5%. When it came to stopping the run, the Texans gave up 85 yds on 23 tries, which is an average of 3.7 yards per run allowed.

When it comes to getting the ball into the endzone, the AFC South members are sitting at 18.5 points per outing. As a unit, they hold an average of 92.0 running yds ranking this team at 25th in the NFL. The Texans have compiled 755 yards on the year. Houston has notched 26 1st downs, and they have been hurt by 16 penalties for 189 yards. They have given the ball to the opposition 2 times. Concerning scoring points, Houston has produced 2 touchdowns via the pass and 2 touchdowns via the ground.

The Texans are ranking 24th in football if you examine the other team scoring points, yielding 28.0 PPG. They are giving up 3.9 yards per run and 85.5 rush yds per game on the year. When examining pass yds, the Texans have given up 505 yards, which is 26th in football. They have allowed 252.5 total yards per contest through the air, and are surrendering a completion% of 66.7%. All in all, they are conceding 338.0 yards per game, which ranks 21st in the NFL. They have granted 4 touchdowns through the air, plus 2 touchdowns to rushers. All in all, they have granted 171 yards via the ground game in 2 outings over the course of this season.

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The Colts step on the gridiron with a record of 0-2 for the season. The last time they stepped on the gridiron, the Colts went home defeated by a final of 33-30 against the Kansas City Chiefs. Daniel Jones (1 TD) finished the contest with 210 yards on 22-31 through the air while his QB rating was 86.8. He had 1 interception and his average yards per pass attempt was 6.8 yds. Jonathan Taylor carried the ball 24 times for 92 yds, walking away from the contest with 3.8 yards per attempt for Indianapolis. Josh Downs was featured in the passing game for the Colts, grabbing 7 balls for 72 yds (10.3 yards per catch). Indianapolis rushed the ball for 3.7 yards per tote, finishing with a total of 119 yards on 32 carries. The Colts finished the game with a total of 329 yards while running 63 plays (5.2 yds per play). The Colts passing defense gave up a completion percentage of 68.1%, relinquishing 371 yds on 32 out of 47 passing. Indianapolis surrendered 29 running attempts for 152 yards (5.2 yards per carry).

If you examine the points being put on the board, the Colts currently rank 11th in football, by tallying 26.5 points per outing. On the year, the Colts have thrown for a total of 359 yards through the air and have an average of 179.5 yards through the air per game, which is good for 25th in the league. They maintain an average of 110.5 rush yds per game, and have carried the football for 221 yards. The Indianapolis Colts hold an average of 290.0 yards per game, which is good for 21st in the league. The Indianapolis offense has granted 59 yards on 9 penalty flags, which is 29th in football if you examine helping out the opposition. They have compiled 2 picks while conceding 1 fumble, and have obtained 20 first downs offensively.

The Colts are allowing 37.0 points per game, putting them 32nd in the league. They have granted 4 touchdowns by way of the pass in addition to 337.5 pass yds per contest, giving them a rank of 32nd in football. Indianapolis has allowed a total of 354 rushing yds (177.0 yds per outing), as well as 4 touchdowns via the ground game for the season. The Colts defense has taken the field for 142 plays from the line of scrimmage, putting them 31st in the league. The D has produced 1 turnover over the course of this season. All in all, they have allowed 74 points in total.

Who will win tonight's Texans-Colts NFL game against the spread?

Guy's Pick: Take the Texans -2.5

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