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Indianapolis Colts vs Washington Commanders Prediction, 10/4/2026 NFL Picks, Best Bets & Odds Week 4
by Guy Bruhn - 9/29/2026

The Indianapolis Colts hit the road to play the Washington Commanders at Tottenham Hotspur Stadium in London, England. Indianapolis opens as 3.5-point favorites. The total has been set at 46.5. This report includes betting predictions and our expert NFL picks for todays game. Read More >>

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Houston Texans vs Indianapolis Colts Prediction, 9/27/2026 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/22/2026

The Houston Texans hit the road to take on the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN. Indianapolis opens this contest as 2.5-point underdogs from Vegas oddsmakers. The betting total is set at 43. This matchup report includes Vegas odds and a free NFL prediction for tonight. Read More >>

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Indianapolis Colts vs Kansas City Chiefs Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2
by Josh Schonwald - 9/15/2026

The Indianapolis Colts take on the Kansas City Chiefs at Arrowhead Stadium in Kansas City, MO. Indianapolis opens as 7-point underdogs from oddsmakers. The total comes in at 47. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Baltimore Ravens vs Indianapolis Colts Prediction, 9/13/2026 NFL Picks, Best Bets & Odds Week 1
by Josh Schonwald - 9/7/2026

The Baltimore Ravens hit the road to play the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN. Indianapolis opens as 3-point underdogs. The over-under has been set at 47.5. This games report has current odds, betting predictions, and free picks against the spread. Read More >>

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Indianapolis Colts vs Houston Texans Prediction, 1/4/2026 NFL Picks, Best Bets & Odds Week 18
by Tony Sink - 1/2/2026

The Indianapolis Colts (8-8) are headed to NRG Stadium on Sunday where they will attempt to beat the Houston Texans (11-5). Indianapolis is 10.5-point underdogs. The over-under is 39. This matchup report includes odds, betting predictions and a free pick against the spread. Read More >>

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Jacksonville Jaguars vs Indianapolis Colts Prediction, 12/28/2025 NFL Picks, Best Bets & Odds Week 17
by Josh Schonwald - 12/25/2025

The Jacksonville Jaguars (11-4) are traveling to Lucas Oil Stadium on Sunday where they will go up against the Indianapolis Colts (8-7). Jacksonville opens as 6.5-point favorites from Vegas oddsmakers. The total comes in at 48.5. This games report has current odds, betting predictions, and free picks against the spread. Read More >>

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San Francisco 49ers vs Indianapolis Colts Prediction, 12/22/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday. Indianapolis is 6-point dogs from Vegas oddsmakers. The total is set at 46.5. This matchup report includes odds, betting predictions and a free pick against the spread. Read More >>

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Indianapolis Colts vs Seattle Seahawks Prediction, 12/14/2025 NFL Picks, Best Bets & Odds Week 15
by Guy Bruhn - 12/11/2025

The Seattle Seahawks (10-3) will take on the Indianapolis Colts (8-5) at Lumen Field on Sunday. Seattle is 13.5-point favorites from Vegas oddsmakers. The total is set at 42.5. This matchup report includes betting lines and our NFL pick of the day for this game. Read More >>

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Indianapolis Colts vs Jacksonville Jaguars Prediction, 12/7/2025 NFL Picks, Best Bets & Odds Week 14
by Guy Bruhn - 12/4/2025

The Jacksonville Jaguars (8-4) will compete against the Indianapolis Colts (8-4) at EverBank Stadium on Sunday. Indianapolis opens as 1.5-point favorites from oddsmakers. The total comes in at 47.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game. Read More >>

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Houston Texans vs Indianapolis Colts Prediction, 11/30/2025 NFL Picks, Best Bets & Odds Week 13
by Tony Sink - 11/25/2025

The Indianapolis Colts (8-3) are hosting the Houston Texans (6-5) at Lucas Oil Stadium on Sunday. Indianapolis is 4.5-point favorites. The total comes in at 44.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner. Read More >>

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Indianapolis Colts vs Kansas City Chiefs Prediction, 11/23/2025 NFL Picks, Best Bets & Odds Week 12
by Tony Sink - 11/19/2025

GEHA Field at Arrowhead Stadium is the location where the Kansas City Chiefs (5-5) will go up against the Indianapolis Colts (8-2) on Sunday. Kansas City opens this game as 3-point favorites from Vegas oddsmakers. The total is 50.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner. Read More >>

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Atlanta Falcons vs Indianapolis Colts Prediction, 11/9/2025 NFL Picks, Best Bets & Odds Week 10
by Guy Bruhn - 11/5/2025

The Atlanta Falcons (3-5) are en route to Olympic Stadium on Sunday where they will compete against the Indianapolis Colts (7-2). Atlanta is 6-point underdogs from Vegas oddsmakers. The over-under is set at 48.5. This report includes betting predictions and our expert NFL picks for todays game. Read More >>

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Indianapolis Colts vs Pittsburgh Steelers Prediction, 11/2/2025 NFL Picks, Best Bets & Odds Week 9
by Guy Bruhn - 10/28/2025

The Indianapolis Colts (7-1) are on their way to Acrisure Stadium on Sunday where they will play the Pittsburgh Steelers (4-3). Pittsburgh opens as 3-point underdogs. The total has been set at 50.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game. Read More >>

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Tennessee Titans vs Indianapolis Colts Prediction, 10/26/2025 NFL Picks, Best Bets & Odds Week 8
by Guy Bruhn - 10/22/2025

The Tennessee Titans (1-6) are en route to Lucas Oil Stadium on Sunday where they will compete against the Indianapolis Colts (6-1). Tennessee opens this matchup as 14-point underdogs from Vegas oddsmakers. The over-under comes in at 47. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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Indianapolis Colts vs Los Angeles Chargers Prediction, 10/19/2025 NFL Picks, Best Bets & Odds Week 7
by Tony Sink - 10/14/2025

The Los Angeles Chargers (4-2) are welcoming the Indianapolis Colts (5-1) at SoFi Stadium on Sunday. Indianapolis opens this contest as 1.5-point underdogs from oddsmakers. The betting total is set at 48.5. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup. Read More >>

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Arizona Cardinals vs Indianapolis Colts Prediction, 10/12/2025 NFL Picks, Best Bets & Odds Week 6
by Josh Schonwald - 10/7/2025

The Arizona Cardinals (2-3) are headed to Lucas Oil Stadium on Sunday where they will go up against the Indianapolis Colts (4-1). Indianapolis opens this matchup as 6.5-point favorites from oddsmakers. The total comes in at 47.5. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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Las Vegas Raiders vs Indianapolis Colts Prediction, 10/5/2025 NFL Picks, Best Bets & Odds Week 5
by Josh Schonwald - 9/30/2025

The Indianapolis Colts (3-1) will try to defeat the Las Vegas Raiders (1-3) at Lucas Oil Stadium on Sunday. Indianapolis opens this matchup as 7-point favorites. The over-under comes in at 48. This matchup report includes football betting lines and our pick of the day for this game.The Indianapolis Colts (3-1) will try to defeat the Las Vegas Raiders (1-3) at Lucas Oil Stadium on Sunday. Indianapolis opens this matchup as 7-point favorites. The over-under comes in at 48. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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Indianapolis Colts vs Los Angeles Rams Prediction, 9/28/2025 NFL Picks, Best Bets & Odds Week 4
by Tony Sink - 9/23/2025

SoFi Stadium is the place where the Los Angeles Rams (2-1) will attempt to defeat the Indianapolis Colts (3-0) on Sunday. Indianapolis is 3.5-point dogs. The total is set at 49.5. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup. Read More >>

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Indianapolis Colts vs Tennessee Titans Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

Nissan Stadium is the place where the Tennessee Titans (0-2) will try to beat the Indianapolis Colts (2-0) on Sunday. Indianapolis opens as 3.5-point favorites. The total comes in at 43.5. This matchup report includes football betting lines and our pick of the day for this game. Read More >>

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Denver Broncos vs Indianapolis Colts Prediction, 9/14/2025 NFL Picks, Best Bets & Odds Week 2
by Guy Bruhn - 9/9/2025

The Denver Broncos (1-0) are on their way to Lucas Oil Stadium on Sunday where they will attempt to beat the Indianapolis Colts (1-0). Denver is 2.5-point favorites from oddsmakers. The total has been set at 42. This matchup report includes Vegas odds and a free NFL pick for tonight. Read More >>

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