Indianapolis Colts vs Kansas City Chiefs Prediction, 9/20/2026 NFL Picks, Best Bets & Odds Week 2

Game: Indianapolis Colts vs Kansas City Chiefs

Date: Sunday, September 20, 2026

Location: Arrowhead Stadium in Kansas City, MO

TV: NBC

Odds-Point Spread: Colts +7.0

Total-Over-Under: 47

The Indianapolis Colts (0-1) are traveling to Arrowhead Stadium on Sunday where they will try to defeat the Kansas City Chiefs (1-0). Indianapolis opens as 7-point underdogs from oddsmakers. The total comes in at 47.

The Indianapolis Colts head into this matchup 0-1 for this campaign. When they last took the field, the Colts faced the Baltimore Ravens and went home with a loss by a final score of 41-23. Jonathan Taylor was the rushing leader for the Colts with 19 totes for 98 yds (5.2 yards per attempt). Keenan Allen held an average of 5.3 yds per reception by earning 32 yards on 6 receptions. Daniel Jones went 19-31 with 166 yds passing and 1 touchdown. He had a quarterback rating of 72.8 and finished the contest with 1 pick. Against the rush, the Colts gave up 202 yds on 37 attempts, which averages out to 5.5 yards per rush surrendered. Indianapolis conceded 17 completions on 25 tries for 304 yds, and a completion percentage of 68.0%. At the end of the game, they ran 51 plays which totaled 251 yds. The Indianapolis Colts ran the rock 20 times and tallied 102 yards, which had them averaging 5.1 yds per carry.

The Colts have accumulated 251 yards over the course of this year. Indianapolis has accumulated 8 1st downs, and they have been hurt by 4 penalties for 29 total yards. Regarding getting the ball in the endzone, Indianapolis has notched 1 passing touchdown and 2 touchdowns via the run. They have surrendered the football 2 different times (1 interception and 1 fumble). As a unit, they maintain an average of 102.0 rush yards putting them 20th in professional football. If you examine getting the ball into the endzone, the AFC South representatives have an average of 23.0 points per outing.

Concerning pass yards, the Colts have yielded 304 yds, putting them 28th in professional football. They have allowed 304.0 yds per contest via the pass, and are giving up a completion% of 68.0%. In total, they have granted 202 yards via the running game in 1 game so far this season. They have granted 1 touchdown through the air, along with 4 touchdowns by way of the ground game. Altogether, they are surrendering 506.0 total yards per outing, ranking this team at 31st in the NFL. They are giving up an average of 5.5 yds per run and 202.0 running yards per contest for the season. The Colts rank 31st in professional football if you examine opponents scoring, allowing 41.0 points per contest.

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The Chiefs head into this matchup 1-0 for this campaign. The last time they stepped on the gridiron, the Chiefs went home victorious with a score of 31-10 when they played the Denver Broncos. Kenneth Walker III carried the rock 23 times for 173 yards, walking away from the game with 7.5 yds per carry for Kansas City. Travis Kelce was the top contributor in the passing game for the Chiefs, snagging 3 balls for 71 yds (23.7 yds per catch). Patrick Mahomes (2 TDs) finished the game with 184 yds on 15-27 passing while his quarterback rating was 86. He had 1 interception and his Y-A was 6.8 yds. Kansas City gave up 15 rushing attempts for 61 yds (4.1 yards per rush). The Chiefs secondary allowed a completion rate of 60.7%, surrendering 115 yards on 17 for 28 passing. The Chiefs finished the game with a total of 392 yds while they ran 65 plays (6.0 yards per play). Kansas City rushed for 5.8 yards per carry, finishing the game with 220 yards on 38 carries.

The Kansas City Chiefs have an average of 392.0 yards per game, which is 9th in pro football. They have an average of 220.0 running yards per game. They have recorded 1 interception and have been able to obtain 7 first downs as an offense. The Kansas City offense has yielded 60 yards by way of 7 penalty flags, putting them 18th in pro football when it comes to helping out the other team. For the season, the Chiefs have thrown for 172 passing yds. In terms of their scoring prowess, the Chiefs sit 10th in professional football, maintaining an average of 31.0 points per outing.

They have relinquished 1 touchdown via the pass and 115.0 passing yds per game, which ranks them at 1st in football. Kansas City has relinquished a total of 61 rush yds. The D has collected 2 turnovers (1 fumble and 1 interception) for this campaign. All in all, they have relinquished 10 pts. The Chiefs defense has participated in 47 plays, ranking this team at 1st in the NFL. The Chiefs are relinquishing 10.0 PPG, which is good for 5th in the league.

Who will win tonight's Colts-Chiefs NFL game against the spread?

Josh's Pick: Take the Colts +7.0

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