Indianapolis Colts vs Minnesota Vikings Prediction, 10/25/2026 NFL Picks, Best Bets & Odds Week 7

Game: Indianapolis Colts vs Minnesota Vikings

Date: Sunday, October 25, 2026

Location: U.S. Bank Stadium in Minneapolis, MN

TV: CBS

Odds-Point Spread: Colts +6.5

Total-Over-Under: 41.5

The Minnesota Vikings (5-0) will play the Indianapolis Colts (2-4) at U.S. Bank Stadium on Sunday. Indianapolis is 6.5-point dogs from Vegas oddsmakers. The total is set at 41.5.

The Indianapolis Colts come into this game holding a record of 2-4 for this campaign. When they last took the field, the Colts played the Tennessee Titans and took a loss by a final of 26-20. Jonathan Taylor was the rushing leader for the Colts with 21 carries for 94 yds (4.5 yds per carry). Keenan Allen averaged 10.3 yds per reception by accounting for 82 yds on 8 receptions. Daniel Jones connected on 22-42 with 269 yards passing and 1 touchdown. He had a quarterback rating of 60.5 and walked away from the contest with 2 picks. When it came to stopping the run, the Colts gave up 84 yards on 23 attempts, which is 3.7 yards per run surrendered. Indianapolis gave up 11 pass completions on 22 attempts for 102 yds, and a completion percentage of 50.0%. In all, they tallied 72 plays which converted into 399 yds. The Indianapolis Colts ran the ball 30 different times and totaled 165 yards, which earned them an average of 5.5 yards per attempt.

The Colts currently have 1,868 yds so far this season. Indianapolis has attained 64 1st downs offensively, and they have committed 30 infractions for 225 yds. When it comes to scoring, Indianapolis has produced 4 passing touchdowns and 9 rushing TD's. They have surrendered the ball 11 times (6 INTs and 5 lost fumbles). Collectively, they maintain an average of 111.5 running yards which has them ranked 16th in football. When talking about getting the ball in the endzone, the team who plays in Indianapolis are sitting at 24.0 points per contest.

When it comes to yards via the pass, the Colts have granted 1,372 yards, which has them ranked 21st in football. They have relinquished 228.7 total yards per contest via the pass, and are conceding a completion percentage of 61.4%. In total, they have granted 735 yards on the ground through 6 outings so far this season. They have surrendered 10 touchdowns through the air, and 6 touchdowns by way of the ground game. All in all, they are conceding 351.2 yds per game, which has them ranked 24th in football. They are allowing an average of 4.8 yards per rush on the ground and 122.5 rush yards per contest so far this season. The Colts currently rank 27th in the league when you look at their defensive prowess, conceding 27.3 points per game.

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The Vikings step on the gridiron with a record of 5-0 over the course of this season. In their last game, the Vikings went home victorious with a score of 23-13 against the New Orleans Saints. Kyler Murray (1 touchdown) ended the game with 229 yds on 24-30 through the air while his QB rate was 109.6. He didn't toss any interceptions and his avg yards per attempt was 7.6 yards. Aaron Jones carried the rock 25 times for 113 yards, finishing the contest with 4.5 yards per attempt for Minnesota. Justin Jefferson was one of the featured targets for the Vikings, snagging 6 throws for 79 yds (13.2 yds per reception). Minnesota rushed the football for 4.3 yards per attempt, finishing with 153 yards on 36 attempts. The Vikings finished with a total of 364 yards and they ran 66 plays (5.5 yds per play). The Vikings pass defense allowed a completion rate of 64.0%, surrendering 87 yards on 16 for 25 passing. Minnesota allowed 17 run attempts for 55 yds (3.2 yds per rush).

The Minnesota Vikings have an average of 283.0 yards per game, which has them ranked 27th in football. They have an average of 116.0 running yards per game, and have rushed for 580 yards. They have thrown 2 interceptions while giving up 2 fumbles lost, and have recorded 42 1st downs as an offense. The Minnesota offense has allowed 250 yds on 30 infractions, which has them ranked 32nd in football when talking about making mistakes. Over the course of this season, the Vikings have thrown for a total of 835 passing yds and hold an average of 167.0 passing yds per contest, ranking this team at 29th in pro football. When it comes to their scoring prowess, the Vikings currently rank 22nd in the league, with 21.8 points per game.

The Vikings are relinquishing 12.8 points per outing, ranking them 1st in football. They have allowed 3 touchdowns via the pass along with 173.2 pass yards per contest, putting them 3rd in pro football. Minnesota has relinquished a total of 433 rush yards (86.6 yards per contest), and 2 touchdowns via the ground game so far this season. The Vikings defense has participated in 281 plays, which has them ranked 1st in football. The D has produced 10 takeaways (4 forced fumbles and 6 INTs) so far this season. In total, they have allowed 64 pts.

Who will win tonight's Colts-Vikings NFL game against the spread?

Guy's Pick: Take the Colts +6.5

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