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Video: NFL Picks - San Francisco 49ers vs Tennessee Titans Prediction, 12/23/2021 Week 16 NFL Best Bet

Posted on December 22, 2021

NFL Picks - San Francisco 49ers vs Tennessee Titans Prediction, 12/23/2021 Week 16 NFL Best Bet

Tennessee Titans vs San Francisco 49ers 12/23/2021. The San Francisco 49ers travel to Nashville, TN to face the Tennessee Titans at 8:20PM EST at Nissan Stadium.

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