Docs Website

54 Years Strong! A Trusted Leader In Sports Picks, Best Bets and Predictions Since 1971.

Main Menu

NFL Betting Predictions: Week 10 Opening Line Report and Best Bets

by Spencer Toth - 11/10/2026

NFL betting predictions Week 10 Trevor Lawrence Jacksonville Jaguars

One of the most effective ways to stay ahead of the books on spreads is by securing closing line value early in the week. The spreads available at kickoff are often incredibly sharp and hard to beat, but even a point or two in our favor on the opening lines can be the difference between winning or losing over the course of the season.

Last week, we posted our second straight 2-1 record with a pair of victories. We took the Cleveland Browns (+2.5) over the New Orleans Saints, and the Browns lost by one point in overtime. We also correctly took the Buffalo Bills (-3) over the Minnesota Vikings on Monday night but fell short of the sweep as the Patriots failed to cover against Green Bay. Before we jump into the Week 10 picks, here are the biggest storylines from around the league in Week 9. 

Doc’s Sports offers NFL expert picks for every game on our NFL predictions page.

  • Jaguars Make Statement: Not only did the Jaguars dominate the Ravens 33-10 on Thursday Night Football, but they also shelled out four draft picks to acquire Jessie Bates III and Jordan Davis. With a stranglehold on the AFC South, Jacksonville is here to stay at the top of the AFC. 
  • Bengals Roar in Madrid: Cincinnati won their fourth straight game with their win over the Falcons in Madrid, extending their lead in the AFC North. Their offense has never been a concern. However, now that their defense is looking competent, Joe Burrow and company may be able to return to the AFC summit. 
  • Mahomes Survives Scare: The Jets and Chiefs traded punts early in their Week 9 meeting, but Kansas City eventually pulled away for a 35-12 victory. Patrick Mahomes suffered a seemingly gruesome elbow injury but ultimately returned to the game and miraculously emerged unscathed. 
  • How Much Worse Can It Get? The Chargers are now 0-8 this year and remain the only winless team after getting steamrolled 44-22 by the Houston Texans. They ended their streak of 37 consecutive possessions without a touchdown, but that is the only positive to take away. 
  • Bears Bulldoze Bucs: Chicago overcame four Caleb Williams interceptions and five total turnovers to prevail 27-24 over Tampa Bay on Sunday Night Football. It wasn’t always pretty, but an early 14-0 lead was enough to get them over the line. 
  • Is This the Year? Josh Allen and the Buffalo Bills have been Super Bowl contenders for the last several seasons but have failed to reach the big game since their four straight Super Bowl losses in the 1990s. The Bills picked up a huge road win over the 6-1 Vikings in Week 9 and held onto top spot in the AFC. 

Now that Week 9 is behind us, it is time to jump into the Week 10 picks against the spread. There are three games that stick out as having early value, but there is no guarantee these lines will still be available when kickoff rolls around. Lock these in now, as even one point of closing line value is all we need to stay in the green. 

Game 1: Los Angeles Rams at Arizona Cardinals

Opening Line: Los Angeles Rams (-9.5)

The Los Angeles Rams picked up a crucial win over the Commanders last week, but it was far from a convincing victory. Their offense has all the pieces they need to succeed, but with Puka Nacua landing on IR and DeVante Adams still on the sidelines, alarm bells are suddenly ringing. Matthew Stafford can still deliver accurate balls from the pocket, but when his receivers are dropping passes, the Rams will struggle to move the football. Arizona is far from a dominant force themselves, but they are capable of pulling off upsets like they did against the Rams on the road in Week 6, and this spread is a little disrespectful. Expecting Los Angeles to march into Arizona and win by double digits is a lot to ask against a competent Cardinals defense, and I never have to be convinced to take the points with the home underdog in a divisional matchup. Carson Beck is in line to make his first career start for Arizona, and assuming Mike LaFleur can protect his rookie quarterback, the Cardinals should be able to keep this one close in Glendale. 

Pick: Arizona Cardinals (+9.5)

Game 2: Seattle Seahawks at Las Vegas Raiders

Opening Line: Seattle Seahawks (-3.5)

The reigning Super Bowl champions are taking on a team that has lost five of their last six games, yet the spread is barely more than a field goal? Make it make sense. Kirk Cousins has been a disaster for the Raiders since cooling off from his hot start, and it is only a matter of time before Fernando Mendoza takes over. Things aren’t going to get any easier against Seattle’s defense which has allowed the fewest passing yards and fewest total yards this season. Expecting the Raiders to even find the end zone once may be too much to ask, and it is not as if the Las Vegas defense is full of superstars. Sam Darnold is set to miss this one for Seattle, but Drew Lock has played three games this year with five touchdowns and no interceptions, and is not a massive downgrade from Darnold. Las Vegas has allowed 30 or more points in six straight games, and it is very hard to see this one staying close. Even if the Seattle offense is unable to reach 30+ points, and the Raiders do find some offensive success themselves, this still shapes up to be a comfortable win for Seattle. Once the public realizes how lopsided this matchup really is, this spread could swell close to a touchdown. 

Pick: Seattle Seahawks (-3.5)

Game 3: Los Angeles Chargers at Baltimore Ravens 

Opening Line: Baltimore Ravens (-5.5)

The 2026 season has not gone to plan for either of these franchises. Los Angeles is the only winless team at 0-8, while the Ravens have lost both Lamar Jackson and Tyler Huntley to injury. Baltimore still has an outside chance to make the playoffs while Los Angeles is playing for nothing but pride, but that doesn’t mean they should be hefty home favorites in this one. The Chargers roster is still playing for their respective futures in the league, and even though things haven’t gone their way, that doesn’t mean they will roll over and give up. Baltimore looked completely outclassed by the Jaguars on Thursday night in Week 9, and even with the extra rest, this spread is still hard to justify. Jacoby Brissett has yet to play for the Ravens and will be thrust into the starting role, but his lack of weapons on offense will limit his ability to spark this franchise. There is no reason the Ravens should be five-and-a-half point favorites against anyone in the NFL, even the Chargers, so we will plug our nose and scoop up the points. 

Pick: Los Angeles Chargers (+5.5)

Season Record: 11-16

Get NFL picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.

 

Most Recent NFL Handicapping

One E-mail A Week Is All You Need!
Our weekly newsletter is loaded with exclusive free picks,insight and advice from our expert handicappers