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2025 San Francisco 49ers Predictions with Odds to Win the Super Bowl and Season Win Totals

by Spencer Toth - 8/15/2025

San Francisco 49ers predictions Brandon Aiyuk

You would be hard-pressed to find a team that had a more disappointing season than the 49ers last year. On second thought, this has been a disappointing team for the last several seasons, as they have been unable to overcome the final hurdle despite possessing a wealth of talent on both sides of the ball. There is optimism in the Bay Area heading into this year, but the fanbase is hesitant to get too excited before they see this team take the field. Can this be the season the 49ers finally get the job done, or will it be back to the drawing board once again come January?

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Offseason Recap

The 49ers were incredibly active in the offseason this year. On offense, their first order of business was shipping Deebo Samuel to the Washington Commanders. Samuel was a useful part of this offense for several years, but it is time for the 49ers to move on to new, younger talent. There is room for promotion within, but one name the 49ers brought in was DeMarcus Robinson. Robinson had a breakout season with the Rams last year, but a looming three-game suspension for a DUI incident has already dented their early aspirations. 

On the defensive side of the ball, the 49ers underwent a complete team overhaul this offseason. They released or traded an astonishing 15 defensive players. The biggest names to leave San Francisco were Dre Greenlaw, Javon Hargrave, Leonard Floyd, and Charvarius Ward. Greenlaw has been a crucial member of the 49ers' defense for the last six seasons and is one of the best linebackers in the league. However, a season-ending injury early last year had the 49ers hesitant to re-sign Greenlaw. Javon Hargrave is also a huge loss, but he was unable to stop the run, and that is now a huge emphasis for the incoming Robert Saleh. 

The 49ers spent their first five draft picks on defensive players, and it was clear their priority was stopping the run. Mykel Williams was drafted 11th overall out of Georgia, and his ability to stop runs both up the gut and on the outside will make him a Week 1 starter for San Francisco. Williams still has time to develop his pass-rush game at 20 years old, and the 49ers will be hoping he can become a well-rounded edge. Building a dominant pass rush around Nick Bosa will always be the 49ers' priority. They have now balanced their defensive line nicely with a rock-solid tackle in Alfred Collins drafted with their second-round pick, and brought in Bryce Huff from the Eagles. If new defensive coordinator Saleh can pick up where he left off in San Francisco, the sky is the limit for this defense. 

Season Expectations

The San Francisco 49ers have much higher season expectations than most teams would after a 6-11 season. They lost seven of their last eight games after starting 5-4 last season, and the 49ers will feel confident they can get back to the playoffs if they can stay out of the infirmary. Christian McCaffrey played only four games last season, while Brandon Aiyuk, Deebo Samuel, Jauan Jennings, and Ricky Pearsall all missed time, too. If that sounds like the top five skill position players in San Francisco, that’s because it was. It is hard to determine what a healthy 49ers team is capable of, and we will still need to wait several weeks at a minimum before we find out. Brandon Aiyuk is injured to start the season and will miss at least a month, while Robinson awaits his suspension for off-field incidents. 

Assuming everyone is healthy, this team is dangerous. McCaffrey has proven he is still among the league’s great running backs and has the potential to single-handedly carry this offense. He is active in both the run game and passing game, and his connection with Brock Purdy continues to flourish. Speaking of Purdy, the 49ers quarterback still has plenty to prove despite receiving a massive $265 million contract this offseason. Purdy is still an average quarterback in the public’s eyes despite taking his team to the Super Bowl and consistently finding ways to win football games. It is easy to point out the offensive talents around him, but there is no denying the impact Purdy has had on this franchise. He is calculated with the football, rarely makes mistakes, and has already proven the naysayers wrong with sustained success. He is still only one year older than Jayden Daniels and Bryce Young, and has plenty of room to grow into a legitimate threat in San Francisco.

San Francisco 49ers Schedule Breakdown

Based on last year’s winning percentages, the San Francisco 49ers have the easiest schedule in the NFL at a combined .415. There are certainly threats in their division with the Rams, Seahawks, and Cardinals, but the 49ers do not face too many other tough opponents this year. The NFC South and AFC South are both dreadful, and the 49ers' final three opponents are all last-place teams thanks to their woeful 2024 season. The Browns, Bears, and Giants round out their schedule, and the 49ers are expected to be favorites in nearly every one of their non-divisional matchups. San Francisco plays the Giants, Panthers, and Browns in November, before getting their bye to get ready for the Titans. There are a handful of very winnable games on their schedule, and the 49ers will look to hover at .500 against their tougher opponents while taking care of business against the minnows. If things fall into place for San Francisco, this team could certainly go from worst to first in the NFC West. 

San Francisco 49ers Odds

The San Francisco 49ers are expected to dramatically improve on their 6-11 showing last season, as their win total is a sky-high 10.5 victories. A healthy 49ers team is capable of reaching this total, but early injuries and a lack of continuity make this a team to fade in the early stages. Not only are the 49ers expected to reach double-digit wins, but they are also the NFC West favorites at +160. Even if they don’t win the division, the 49ers have -200 odds to reach the playoffs. In the playoffs, the 49ers have the 7th-best odds to win the Super Bowl at +2000, with +750 odds to win the NFC. It is easy to forget the 49ers were one of the Super Bowl favorites heading into the season in each of the last three years, and a revamped defense could see them ascend back to the top of the league later this year. 

2025 San Francisco 49ers Season Predictions and Best Bets

The 49ers will probably be better than 6-11 this season, but tailing them at these inflated prices simply isn’t an option. The 49ers may have been able to draft well to fix their issues on the defensive side of the ball, but I have absolutely zero confidence in their offense. Purdy’s massive contract meant the 49ers had to be particular with their offseason signings, and they can’t even trust their current offensive talents to stay healthy. One injury for the 49ers will quickly expose their lack of depth, and I will be fading this team at every chance I get. The first pick to make is an easy one, but it won’t be for the 49ers to finish with under 10.5 wins at -130. Instead, we will chase the plus money with Under 9.5 wins at +140. Shooting for the bigger payout is always the move with season-long futures, and even a moderate improvement from this team could still see them fail to reach double-digit victories. A 9-8 season or worse is certainly possible, but the even better pick to make is for the 49ers to miss the playoffs at +160. We saw the Seahawks miss the playoffs with a 10-7 record last year, and 9-8 is unlikely to get the job done. I am not sure why we are getting even better odds on missing the playoffs compared to their Under, but I will not be complaining. Not only is the 49ers missing the playoffs my favorite pick for this team, but it is one of my most confident in the entire NFL heading into the season. 

Pick: San Francisco 49ers Under 9.5 wins +140

Top Pick: San Francisco 49ers to Miss the Playoffs +160

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