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2025 Buffalo Bills Predictions with Odds to Win the Super Bowl and Season Win Totals

by Ryan Cobbett - 7/29/2025

Buffalo Bills predictions Josh Allen

After a mere 3-2 start in 2024, the Bills finished the regular season on a 10-2 run while never losing a game at home. Their +157-point differential was tied for the best mark in the AFC while their offense led the conference with 525 points scored. The Bills joined the Kansas City Chiefs as the only teams to go undefeated at home. Unfortunately for Buffalo, despite another dominant showing in the regular season, they failed to reach the Super Bowl once again. They took care of business against Denver in the first round, snuck by Baltimore in the second, but fell to the Chiefs in the Conference Championship thanks to some questionable calls late in the game.

Josh Allen finished with 3,731 yards in the air last season while adding another 531 yards on the ground, finishing with 40 total touchdowns. He minimized turnovers, throwing just six interceptions in 483 pass attempts and he was sacked just 14 times last season. James Cook was one of 16 running backs to reach the 1,000-yard milestone last season as he finished with 1,009 yards and he was tied for the league lead in rushing touchdowns with 16. Despite missing Stefon Diggs and Gabe Davis, Allen found new connections with many receivers last season as there were nine different receivers to record more than 200 receiving yards last season. Khalil Shakir led the way with 821 yards while recording four touchdowns. Keon Coleman finished second on the team with 556 yards and four touchdowns. Mack Hollins led the receiver room with five receiving touchdowns on the year.

Buffalo’s defense was not the best. They allowed 341.5 YPG and 21.6 PPG last season with the biggest weakness being in the secondary. Buffalo ranked 24th in the NFL in passing yards allowed per game, though they did benefit from leading the league in turnover differential (+24). Dorian Williams led the team with 117 tackles, and he was joined by Terrel Bernard as the two lone Bills players to reach the 100+ tackle mark. Bernard’s 104 tackles also came with two interceptions and three pass deflections. The defense finished with 16 interceptions, two of which were returned to the end zone. Greg Rosseau led the team with eight sacks while Von Miller and AJ Epenesa followed close behind with six.

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Key Additions/Losses

The Bills lost Hollins to the division rival New England Patriots while Amari Cooper will also be absent from the wide receiver room this season. On defense, Buffalo is losing Miller along with a lot of depth up front as Quinton Jefferson, Austin Johnson, Jordan Phillips, and Dawuane Smoot are no longer with the team. The Bills also traded Kaiir Elam to the Dallas Cowboys and Rasul Douglas is currently a free agent.

After losing Hollins and Cooper, the Bills addressed the depth concern in the wide receiver room by adding Elijah Moore and Josh Palmer via free agency. The defense also got a boost upfront as the Bills won the Joey Bosa sweepstakes while they also added depth pieces in Michael Hoecht and Larry Ogunjobi. Shaq Thompson joins the team after appearing in just six games over the last two seasons and the Bills also brought back Tre’Davious White on a one-year deal.

New Kids on the Block

The Bills drafted Maxwell Hairston with the 30th pick in the first round of the NFL Draft in hopes of boosting the secondary. The former Kentucky Wildcat had an incredible 40-yard dash time, and he should excel as a slot corner thanks to his closing speed. Buffalo then continued to address the defensive line with the next three picks as they drafted T.J. Sanders (South Carolina), Landon Jackson (Arkansas), and Deone Walker (Kentucky), sticking to an SEC themed reinforcement. The rest of their draft class includes Jordan Hancock (CB, Ohio State), Jackson Hawes (TE, Georgia Tech), Dorian Strong (CB, Virginia Tech), Chase Lundt (OT, UConn), and Kaden Prather (WR, Maryland).

X-Factors

Wide Receiver- Who is going to step up and be the star to elevate this wide receiver room and Josh Allen’s offense? Shakir looks to be that guy as he is slated to be WR1 in Buffalo once again this season. Palmer also comes in as an underrated signing as he is a solid long ball threat for Allen which could open things up for Shakir to get open and pad the stats.

Defense- The Bills defense was not very good last season and aside from bringing in Bosa, the defense once again projects to be shaky. Now, they have the offense to combat this and the defense did add some exciting young talent in Hairston and Sanders, but they need to find their way past Kansas City and Baltimore in route to a potential Super Bowl appearance.

Notable Odds

Super Bowl Winner: +700

AFC Champion: +340

AFC East Winner: -290

NFL MVP- Josh Allen: +600

AP Offensive Player of the Year- James Cook: +7500

AP Defensive Rookie of the Year- Maxwell Hairston: +3000

Schedule Breakdown

Predicted Win Total: 11.5 Games

The schedule for Buffalo is highly favorable thanks to the status of their division foes. The Patriots are on the rise, but both the New York Jets and Miami Dolphins seem to have regressed. It won’t be surprising to see Buffalo dominate their division foes with their most difficult contest amongst them coming in Week 15 in New England. A 4-2 or better division record seems highly likely. As for the remaining schedule, they have one of the easiest stretches in the league from Week 2 through Week 8. Over that seven week stretch, the Bills have road games against the Jets, Falcons, and Panthers while they host the Dolphins, Saints, and Patriots and a Bye Week sandwiched in there as well. All it takes is a quick glance to realize Buffalo has no obvious loss on the schedule and about 10 wins. The toughest opponents on their schedule, Baltimore, Kansas City, and Philadelphia, will have to come to Buffalo. The Bills Week 13 matchup against the Steelers will be a solid matchup as Buffalo will head to Pittsburgh to face the Aaron Rodgers led squad. Buffalo’s win total is not likely to change much from last seasons (13).

2025 Buffalo Bills predictions Prediction

With the win total set at 11.5 and 10 obvious wins on the schedule, it is hard to see Buffalo falling short of the Over here. The offense should once again dominate and the defense, specifically the secondary, may have received a boost during the offseason with the additions of Bosa and Hairston. Even with a bad defense the Bills still won 13 games last season, and they have the benefit of a weak division and favorable matchups playing their toughest opponents at home. At +340, there is value in taking Buffalo to win the AFC and find their way to the Super Bowl. The tools are in place and the schedule is favorable for Buffalo to potentially snag the top seed in the conference heading into the playoffs. This team is a legit Super Bowl contender again this season. Go all in on the Over 11.5 for the win total and take some fliers for a AFC and Super Bowl win.

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