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San Francisco 49ers vs Arizona Cardinals Prediction, 11/21/2022 NFL Picks, Best Bets & Odds Week 11

by Guy Bruhn - 11/14/2022

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Game: San Francisco 49ers vs Arizona Cardinals

Date: Monday, November 21, 2022

Location: Estadio Azteca in Mexico City, Mexico

TV: ESPN

Odds/Point Spread: Cardinals (+1.5)

Total/Over-Under: 46.5

The San Francisco 49ers (5-4) are en route to Estadio Azteca on Monday where they will try to beat the Arizona Cardinals (4-6). San Francisco opens this game as 1.5-point favorites from oddsmakers. The total is set at 46.5.

The San Francisco 49ers step onto the field holding a record of 5-4 this year. In their last contest, the 49ers faced the Chargers and took home the win by a score of 22-16. Jimmy Garoppolo finished 19/28 with 240 yds passing. He had a QB rate of 94.3 and ended the game with no picks. Elijah Mitchell was the rushing leader for the 49ers with 18 attempts for 89 yds (4.9 yds per carry). Brandon Aiyuk had an average of 14.0 yds per catch by earning 84 yds on 6 catches. The San Francisco 49ers ran the rock 41 different times and totaled 157 yards, which had them averaging 3.8 yards per carry. For the game, they ran 70 plays for 387 yards. San Francisco allowed 21 completions on 37 attempts for a total of 187 yards, and a completion rate of 56.8%. In the running game, the 49ers conceded 51 yds on 16 tries, which is an average of 3.2 yards per rush surrendered.

The 49ers have earned 3,240 total yards for the season. San Francisco has tallied 98 1st downs as a team, and they have been flagged for 56 infractions for 410 yds. When it comes to getting the ball in the endzone, San Francisco has earned 12 touchdowns through the air and 9 touchdowns on the ground. They have surrendered the ball 13 times (6 picks and 7 fumbles). As a team they maintain an average of 123.7 yards on the ground ranking them 14th in the league. Concerning scoring, the San Francisco 49ers are averaging 22.0 points per game.

In terms of yards through the air, the 49ers have surrendered 1,781 yards which has them ranked 4th in the NFL. They have surrendered 197.9 yards per game via the pass as well as giving up a completion percentage of 65.3%. Overall, they have yielded 280.6 yards per contest which puts them 1st in the National Football League. They have given up 9 touchdowns via the pass and 8 touchdowns pounding the rock. They are allowing teams to run for an average of 3.4 yards per tote and 82.7 yards on the ground per game for the year. During this campaign, they have allowed 744 rushing yards through 9 games. The 49ers rank 5th in the NFL regarding team defense, conceding 18.1 points per game.

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The Cardinals come into this matchup with a record of 4-6 for this season. In their last contest, the Cardinals got the victory with a final of 27-17 when they played the Rams. Colt McCoy (1 TD) finished the contest with 238 yds on 26/37 through the air while his QB rating was 96.5. He kept the ball away from the defense with no picks and his avg yards per attempt was 6.4 yards. James Conner carried the ball 21 times for 69 yards, ending the contest with 3.3 yards per attempt for Arizona. DeAndre Hopkins was one of the featured targets for the Cardinals, catching 10 balls for 98 yds (9.8 yds per catch). Arizona ran the ball for 3.0 yards per attempt, finishing with a total of 78 yards on 26 carries. The Cardinals finished the game with a total of 298 yds and they ran 65 plays (4.6 yds per play). The Cardinals pass defense allowed a completion percentage of 67.6%, relinquishing 190 yds on 25 out of 37 through the air. Arizona relinquished 20 rush attempts for 66 yards (3.3 yds per carry).

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The Arizona Cardinals average 333.7 yards/game which has them sitting 19th out of all teams in the league. They hold an average of 113.1 rushing yards per game and have toted the ball for 1,131 yards in total. The Arizona offense has 579 penalty yards on 74 infractions, which is good for 2nd in football in terms of helping out the opposition. They have given away 6 interceptions while surrendering 3 fumbles and they have been able to record 121 first downs. For the year thus far, the Cardinals have a total of 2,206 yards via the pass not to mention holding an average of 220.6 passing yards per contest, ranking them 18th out of all NFL teams. In relation to the points being put on the board, the Cardinals are ranking 13th out of all teams in the league with an average of 23.0 points per game.

The Cardinals are conceding 25.8 points per game, which puts them in 30th of all teams in the NFL. They have surrendered 17 touchdowns from the passing game as well as 247.1 yards/outing, which has them ranked 23rd out of all teams. This season, they have given up 258 points in total. Arizona has surrendered a total of 1,105 rushing yards (110.5 yards per contest) and 12 touchdowns by way of the ground game for the year. The Cardinals defense has participated in 630 plays, which is good for 28th in football. They have 14 takeaways (7 fumbles and 7 picks) over the course of the season.

Who will win tonight's 49ers/Cardinals NFL game against the spread?

Guy's Pick: Take the Cardinals +1.5

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