NFL Picks: Parlays, Best Bets, Player Props, and Expert Predictions Against the Spread.

Green Bay Packers vs Cleveland Browns Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

Huntington Bank Field is the place where the Cleveland Browns (0-2) will try to beat the Green Bay Packers (2-0) on Sunday. Green Bay opens this matchup as 8-point favorites from Vegas oddsmakers. The total comes in at 42. This report includes betting predictions and our expert NFL picks for todays game.

Atlanta Falcons vs Carolina Panthers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

The Carolina Panthers (0-2) will compete against the Atlanta Falcons (1-1) at Bank of America Stadium on Sunday. Atlanta opens this contest as 5-point favorites from Vegas oddsmakers. The total comes in at 43.5. This report has odds and your NFL football predictions for todays game against the spread.

Pittsburgh Steelers vs New England Patriots Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

The New England Patriots (1-1) will play the Pittsburgh Steelers (1-1) at Gillette Stadium on Sunday. New England opens this game as 1-point dogs from Vegas oddsmakers. The total is set at 44.5. This matchup report includes Vegas odds and a free NFL prediction for tonight.

New York Jets vs Tampa Bay Buccaneers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

Raymond James Stadium is the location where the Tampa Bay Buccaneers (2-0) will try to beat the New York Jets (0-2) on Sunday. Tampa Bay opens this game as 7-point favorites from oddsmakers. The total comes in at 45.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner.

Dallas Cowboys vs Chicago Bears Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

The Dallas Cowboys (1-1) are headed to Soldier Field on Sunday where they will compete against the Chicago Bears (0-2). Chicago is 1-point underdogs. The total comes in at 50. This report includes betting odds and our expert football picks for todays game.

New Orleans Saints vs Seattle Seahawks Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

The New Orleans Saints (0-2) are on their way to Lumen Field on Sunday where they will try to defeat the Seattle Seahawks (1-1). Seattle opens this matchup as 7.5-point favorites from Vegas oddsmakers. The total is 41.5. This matchup report includes odds, NFL betting predictions and a free pick against the spread.

Houston Texans vs Jacksonville Jaguars Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

The Houston Texans (0-2) are en route to EverBank Stadium on Sunday where they will meet the Jacksonville Jaguars (1-1). Jacksonville opens this contest as 1-point favorites from Vegas oddsmakers. The total comes in at 44.5. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup.

Los Angeles Rams vs Philadelphia Eagles Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

The Los Angeles Rams (2-0) are en route to Lincoln Financial Field on Sunday where they will meet the Philadelphia Eagles (2-0). Philadelphia opens this contest as 3.5-point favorites from Vegas oddsmakers. The betting total is set at 44.5. This games report has current odds, betting predictions, and free picks against the spread.

Las Vegas Raiders vs Washington Commanders Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

The Washington Commanders (1-1) will play the Las Vegas Raiders (1-1) at Northwest Stadium on Sunday. Las Vegas is 3.5-point dogs from Vegas oddsmakers. The betting total comes in at 44.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game.

Arizona Cardinals vs San Francisco 49ers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

Levi's Stadium is the place where the San Francisco 49ers (2-0) will attempt to beat the Arizona Cardinals (2-0) on Sunday. Arizona opens this game as 1.5-point underdogs from oddsmakers. The total is set at 43.5. This matchup report includes betting lines and our NFL pick of the day for this game.

Kansas City Chiefs vs New York Giants Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

The Kansas City Chiefs (0-2) are headed to MetLife Stadium on Sunday where they will attempt to defeat the New York Giants (0-2). Kansas City opens this matchup as 5.5-point favorites from oddsmakers. The total has been set at 45.5. This matchup report includes Vegas odds and a free NFL pick for tonight.

Miami Dolphins vs Buffalo Bills Prediction, 9/18/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

The Buffalo Bills (2-0) welcome the Miami Dolphins (0-2) at Highmark Stadium on Thursday. Miami opens this matchup as 12.5-point underdogs from Vegas oddsmakers. The total is 49.5. This matchup report includes NFL odds, predictions, and a free pick against the spread.

Indianapolis Colts vs Tennessee Titans Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Josh Schonwald - 9/16/2025

Nissan Stadium is the place where the Tennessee Titans (0-2) will try to beat the Indianapolis Colts (2-0) on Sunday. Indianapolis opens as 3.5-point favorites. The total comes in at 43.5. This matchup report includes football betting lines and our pick of the day for this game.

Cincinnati Bengals vs Minnesota Vikings Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Parlays Pundit - 9/16/2025

U.S. Bank Stadium is the location where the Minnesota Vikings (1-1) will attempt to beat the Cincinnati Bengals (2-0) on Sunday. Cincinnati opens this contest as 3-point underdogs. The total is 42. We have included an expert NFL pick and parlay for todays game against the spread.

Denver Broncos vs Los Angeles Chargers Prediction, 9/21/2025 NFL Picks, Best Bets & Odds Week 3
by Guy Bruhn - 9/16/2025

SoFi Stadium is the location where the Los Angeles Chargers (2-0) will try to beat the Denver Broncos (1-1) on Sunday. Los Angeles opens this game as 2.5-point favorites from Vegas oddsmakers. The total is 46. This matchup report includes Vegas odds and a free NFL pick for tonight.

Detroit Lions vs Baltimore Ravens Prediction, 9/22/2025 NFL Picks, Best Bets & Odds Week 3
by Tony Sink - 9/16/2025

The Detroit Lions (1-1) are on their way to M&T Bank Stadium on Monday where they will try to defeat the Baltimore Ravens (1-1). Baltimore is 5.5-point favorites. The total comes in at 51.5. This matchup report includes odds, betting predictions and a free pick against the spread.