NFL Office Pool Picks Week 5 - ATS Predictions for Every Game!

There is nothing more impressive in the world of sports betting than winning a season-long office pool. With 272 games against the spread to pick, it won’t be one lucky break or bad beat that separates the contenders from the pretenders. By following this weekly segment, you will be able to maximize your chances of winning your office pool after we went 142-125-5 last season. In Week 4, we went 9-7 against the spread for our third straight positive week. We also nailed our first exact score of the season, calling a 34-10 Lions’ victory over the Browns. A poor Week 1 means we are back to 32-32 on the season, but we are heading in the right direction as we search for a fourth straight winning week. Around the NFL, favorites went 10-5-1 straight up, and 9-7 against the spread. The Week 5 lines are out, so let’s dive right into your office pool picks against the spread.
Doc’s Sports offers NFL expert picks for every game on our NFL predictions page.
San Francisco 49ers (+6.5) Over Los Angeles Rams
The Rams deserve to be the favorites on Thursday night, but this spread is a tad wide for a team as talented as the 49ers. The Rams were fortunate to escape with a victory against the Colts last week, and expecting another victory by at least a touchdown is a lot to ask. The 49ers are far from healthy at this stage of the season, but they are still capable of keeping this one close most of the way. Rams 24, 49ers 20
Minnesota Vikings Over Cleveland Browns (-3.5)
The Vikings have the advantage of plenty of preparation for this game after facing off against the Steelers last week in Dublin. It isn’t hard to fade the Browns offense right now, and I expect another dominant showing from the Minnesota defense. The Vikings are the better team on both sides of the ball, and a short spread on a neutral site makes them the only option. Minnesota 27, Browns 13
Baltimore Ravens (+1.5) Over Houston Texans
Lamar Jackson won’t be playing in this one, but the Ravens as a home underdog is something we still can’t pass up. Baltimore has a wide range of offensive talents, and don’t let a 26-0 beatdown against the Titans trick you into thinking the Texans are good. Even without Lamar Jackson, the Ravens have the better offense, and it is only a matter of time before their defense steps up. It’ll be close, but the Ravens take a crucial victory with 5+ sacks on CJ Stroud. Ravens 20, Texans 17
New York Giants (+1.5) Over New Orleans Saints
The Giants have a win and new optimism with Jaxson Dart, while the Saints are still waiting for this season to be over. Losing Malik Nabers will be hard to overcome, but the Giants still have enough firepower around Dart for the rookie to succeed. Meanwhile, there are very few bright spots in New Orleans, and we will fade them in the favorite role. Giants 29, Saints 21
Miami Dolphins (-1.5) Over Carolina Panthers
Miami is unlikely to make the playoffs this season, but they are playing better football than the Panthers. Even without Tyreek Hill, the Dolphins have the better offensive weapons, and the Panthers have struggled to slow down dual-threat running backs. Tua Tagovailoa and the Dolphins looked great last week for their first win of the season, and we will ride the hot hand in this one. Dolphins 27, Panthers 20
Indianapolis Colts (-6.5) Over Las Vegas Raiders
Costly penalties cost the Colts last week, but they will bounce back against a helpless Raiders side. Geno Smith is playing the worst football of his career, and the Raiders' run game has done him no help either. The Colts will smother Las Vegas from the opening kickoff, and a few nice throws down the field from Daniel Jones will be enough to claim a win and cover. Colts 33, Raiders 18
Philadelphia Eagles (-4.5) Over Denver Broncos
The Eagles keep finding ways to win football games, and they have shown a level of grit the Broncos are still missing. The AJ Brown saga is certainly a distraction, but the Eagles still have the roster they need without Brown playing at his best. This is a relatively short spread for Philadelphia at home, and there aren’t enough points to consider taking a shot with a Denver upset. Eagles 28, Broncos 17
Dallas Cowboys (-2.5) Over New York Jets
Dallas and New York are heading in two different directions, and this is the most confident spread pick of the week. Dallas has an explosive offense that will not be contained, while Justin Fields struggles to find the same accuracy down the field. Dak Prescott just lit up a seemingly dominant Packers defense, and will be able to pile on the points in this one too. The struggling Cowboys defense will keep the Jets in the game for a while, but it is only a matter of time before Dallas pulls away. Cowboys 35, Jets 17
Tennessee Titans (+8.5) Over Arizona Cardinals
The Titans' offense has been historically bad, but it is not as if the Cardinals have been blowing teams out of the water this season either. Arizona has had an easy strength of schedule thus far, yet it still hasn’t been able to find its offensive groove. They can’t be trusted to win by double digits against anyone right now, and the Titans' defense isn’t as bad as the numbers suggest. Cardinals 20, Titans 15
Tampa Bay Buccaneers (+3.5) Over Seattle Seahawks
The Buccaneers’ physical playstyle will allow them to win this one outright. Seattle shouldn’t be favored by more than a field goal against Tampa Bay, which consistently plays tough football regardless of the opponent or venue. There are still some question marks surrounding Sam Darnold in this offense, and I have far more trust in Baker Mayfield to get the job done in the fourth quarter than I do anyone on the Seahawks. It’ll be close, but the crucial number on the spread pushes this one in favor of Tampa Bay. Buccaneers 27, Seahawks 26
Los Angeles Chargers (-2.5) Over Washington Commanders
Jayden Daniels is expected back for this matchup, but it won’t be enough for the Commanders to win or cover. Washington’s defensive injuries, combined with poor play from their veteran players, have left them exposed on that side of the ball. Justin Herbert has the downfield accuracy to take advantage, and this is a soft spread for Los Angeles at home. Maybe Jayden Daniels finds a way to play hero, but more often than not, the Chargers secure the win and cover. Chargers 32, Commanders 28
Cincinnati Bengals (+10.5) Over Detroit Lions
This is an ugly pick for late Sunday afternoon, but one we have to make. Cincinnati looked incredibly flat on Monday night, but a few comments from Chase and their other stars have me expecting a much better effort here. Jake Browning has more to offer than he has shown since taking over, and the Bengals are due for a few bounces to go their way. It won’t take much to cover this spread. Lions 24, Bengals 17
New England Patriots (+8.5) Over Buffalo Bills
The Bills haven’t been covering large spreads this season, and a divisional game will be tighter than this spread suggests. Drake Maye is fourth in the NFL in passer rating this season, and once the Patriots cut down on fumbles, they will be a force in the AFC East. The Bills don’t have the roster depth to run away with this one, and the Patriots may even be able to pull off this upset. Patriots 24, Bills 23
Kansas City Chiefs (-3) Over Jacksonville Jaguars
The Chiefs' demolition of the Ravens got overshadowed by Lamar Jackson’s injury, but they were thoroughly beating their AFC rivals before Jackson went down. The Chiefs' offense came to life while their defense did its job, while the Jaguars barely squeaked past the misfiring 49ers. This is a great Monday Night Football affair, and one where the Chiefs will win and cover by the finest of margins. Chiefs 24, Jaguars 20
Season Record: 32-32
Last Season Record: 142-125-5
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