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NFL Office Pool Picks Week 1 - ATS Predictions for Every Game!

by Spencer Toth - 8/25/2025

NFL office pool picks Week 1 Josh Allen Buffalo Bills

It has been a long 205 days since the Philadelphia Eagles squashed the Kansas City Chiefs in Super Bowl LIX. With a new season on the horizon, your NFL office pool picks are locked in and ready to go for Week 1. Last season, we went 142-125-5 against the spread, improving our 136-128-8 record from the year before. Winning your against the spread office pools takes a season of dedication, and your season will not be determined by one week, bad or good. Doc’s Sports will be releasing against the spread office pool picks for every game this season, and this advice will help you maximize your chances at coming out on top this season. 

Doc’s Sports offers NFL expert picks for every game on our NFL predictions page.

Dallas Cowboys (+6.5) Over Philadelphia Eagles

We are going to be fading the reigning Super Bowl champions in Week 1. The Eagles are deserving favorites at home over Dallas, but this spread is a bit thick for the first week of the season. The Cowboys dealt with numerous injury issues last season, and they are now healthy and ready to go with some crafty offseason moves. This game will be a lot closer than the spread suggests, and it wouldn’t be surprising to see Dallas pull off the outright victory. Cowboys 24, Eagles 21

Kansas City Chiefs (-3) Over Los Angeles Chargers

This is a soft line for the Chiefs for their Friday night matchup in Brazil against the Chargers. The international component can always throw an extra variable in the mix, but the Chiefs are the better team on both sides of the ball. The extra motivation for Kansas City after their poor Super Bowl showing is the cherry on top. Los Angeles will be unable to protect Justin Herbert after Rashawn Slater got hurt in the preseason, and this one could get ugly in a hurry. Chiefs 28, Chargers 13

Washington Commanders (-6.5) Over New York Giants

Terry McLaurin has signed a new contract for Washington, and the team can now dial in their focus for this Week 1 matchup. The Giants have gotten better on the defensive side of the ball, but the Commanders have the offensive line they need to slow down the Giants’ pass rush. A healthy Jayden Daniels will look even better in his second season, and the Commanders will win by two scores in front of a wild home crowd. Commanders 27, Giants 17

Carolina Panthers (+3) Over Jacksonville Jaguars

The Panthers defense still needs some work, but there is no way the Jaguars can be field goal favorites against anyone in the league. Jacksonville simply hasn’t gotten the success they imagined when they drafted Trevor Lawrence. A generous Panthers defense will give the Jacksonville quarterback a chance to shine, but it will be Bryce Young’s offense that comes out on top. Buckle up for a shootout where the Panthers prevail with a late field goal. Panthers 38, Jaguars 35

Pittsburgh Steelers (-3) Over New York Jets

The Steelers will be hoping Aaron Rodgers is the answer to their ongoing quarterback crisis. Rodgers certainly has the defense on the other side of the ball needed to beat down on his former team, and this is exactly the type of game the Steelers know how to win. The Jets have no hope of a respectable season this year, and it will all start with a home loss in Week 1. Steelers 23, Jets 17

New England Patriots (-2.5) Over Las Vegas Raiders

Drake Maye was often overlooked in a solid rookie class, but he will start to take over this year in New England. The Patriots addressed their major areas of need on both sides of the ball this offseason, and will start the year with a solid home victory. It will take time for a new-look Raiders offense to really hit their stride, and they are a great team to fade during the early stages of the season. Patriots 27, Raiders 13

New Orleans Saints (+5.5) Over Arizona Cardinals

The Saints are expected to be one of the worst, if not the worst, teams in the league this season. They have no suitable options at quarterback and the injuries are already piling up before a ball has been kicked. Despite this, the Cardinals can’t be big road favorites after a mediocre season last year. Kyler Murray will never reach his pre-draft expectations, and will find himself in a close game with the lowly Saints. Arizona will win, but the Saints will cover. Cardinals 20, Saints 17

Cincinnati Bengals (-5.5) Over Cleveland Browns

Joe Flacco is an experienced veteran, but he will be no match for Joe Burrow and Ja’Marr Chase. The Bengals defense will certainly make mistakes, but Burrow and company are good enough to outscore their flaws. This is a thick spread for a divisional game, but I just don’t see how the Browns will be able to keep up offensively. Bengals 38, Browns 20

Miami Dolphins (+1.5) Over Indianapolis Colts

This is as close to a toss up as you can get, but we will side with the Dolphins on the road. Miami has the offense needed to break down the Colts, and Indianapolis thrives on shutting down the run over the pass. The Dolphins love to sling it through the air, but Daniel Jones will struggle in his first game under center with his new team. This one will be close, but we have to take the Dolphins straight up and the short spread is a nice bit of insurance. Dolphins 21, Colts 20

Tampa Bay Buccaneers (-1.5) Over Atlanta Falcons

The Falcons were handcuffed in the offseason with Kirk Cousins’ massive contract still on their books. They were unable to make the roster changes needed to solidify their defense as a result, and this will be the start of a disappointing season. Baker Mayfield has no shortage of pass-catching options, and Tampa Bay will bully their way to victory in Atlanta. Buccaneers 30, Falcons 21

Denver Broncos (-7.5) Over Tennessee Titans

Sean Payton does a great job at torching rookie quarterbacks, and Cam Ward will be in for a rude awakening as he makes his NFL debut. This Broncos team could finally end the Chiefs’ reign on top of the AFC West, and they will put together a statement win in Week 1. The Titans earned the first overall pick for a reason last year, and will struggle to get going on either side of the ball. Broncos 29, Titans 11

Seattle Seahawks (+2.5) Over San Francisco 49ers

This is a disrespectful line for Seattle at home. The 49ers are incredibly banged up on offense, they have an incomplete defense, and are still road favorites in this matchup. Meanwhile, Seattle has a new-look offense that may take a drive or two to get going, but their defensive continuity will disrupt the 49ers. Sam Darnold has plenty to prove, and will be effective in his Seahawks debut. Seahawks 17, 49ers 14

Detroit Lions (+1.5) Over Green Bay Packers

It is shocking to see the Lions as an underdog against the Packers in Week 1. Detroit collapsed with a 4-0 turnover differential in the NFC championship game, but that doesn’t take away from what this team is capable of. They are better on offense, defense, and special teams, and this is one of the best picks you can make. The new coordinators have plenty of weapons at their disposal, and will edge out the Packers at Lambeau Field. Lions 28, Packers 25

Houston Texans (+2.5) Over Los Angeles Rams 

The Rams are expected to be a real contender in the NFC this season, but the Texans have just as much hype in the AFC too. Matthew Stafford isn’t getting any better, and a fresh set of weapons on offense may take some time to gel. Meanwhile, the Texans have a similar roster to last season, but now they have had time to heal their injuries. A healthy Houston side will put the league on notice with a big Week 1 victory. Texans 30, Rams 17

Baltimore Ravens (+1.5) Over Buffalo Bills 

The Bills are at home and slight favorites as a result, but it will be Baltimore that wins a crucial Week 1 matchup between these AFC contenders. A rested Lamar Jackson and Derrick Henry are a frightening duo, and the Bills don’t have the same offensive depth as the Ravens. This will be a very tightly contested matchup, but the Ravens’ superiority on both sides of the ball makes them the pick. Ravens 24, Bills 21

Chicago Bears (+1.5) Over Minnesota Vikings

The Bears had several heartbreaking losses last season that were difficult to swallow. While the Vikings were able to consistently win one-score games, Caleb Williams and the Bears fell short. Chicago is one of my Super Bowl sleepers to make a deep run this year thanks to a new coach and a fresh start for Williams. JJ McCarthy simply cannot be a road favorite against a dangerous Bears team, and Chicago will pull off the minor upset at home. Bears 27, Vikings 20

Season Record: 0-0

Last Season Record: 142-125-5 

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