NFL Picks: Parlays, Best Bets, Player Props, and Expert Predictions Against the Spread.

Las Vegas Raiders vs Houston Texans Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/18/2025

The Las Vegas Raiders (2-12) are headed to NRG Stadium on Sunday where they will go up against the Houston Texans (9-5). Houston opens as 14.5-point favorites from Vegas oddsmakers. The total comes in at 38. This matchup report includes betting lines and our NFL pick of the day for this game.

Philadelphia Eagles vs Washington Commanders Prediction, 12/20/2025 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/18/2025

The Philadelphia Eagles (9-5) are headed to Northwest Stadium on Saturday where they will compete against the Washington Commanders (4-10). Philadelphia opens this matchup as 6.5-point favorites from Vegas oddsmakers. The over-under comes in at 44.5. This matchup report includes football betting lines and our pick of the day for this game.

New England Patriots vs Baltimore Ravens Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

The Baltimore Ravens (7-7) are welcoming the New England Patriots (11-3) at M&T Bank Stadium on Sunday. Baltimore is 3-point favorites from Vegas oddsmakers. The total comes in at 48. This game report has an NFL football pick, betting odds, and predictions for tonights key matchup.

Los Angeles Chargers vs Dallas Cowboys Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/18/2025

AT&T Stadium is the place where the Dallas Cowboys (6-7) will meet the Los Angeles Chargers (10-4) on Sunday. Los Angeles is 2.5-point dogs from oddsmakers. The over-under has been set at 49.5. This matchup report includes Vegas odds and a free NFL prediction for tonight.

Pittsburgh Steelers vs Detroit Lions Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

The Pittsburgh Steelers (8-6) are en route to Ford Field on Sunday where they will try to beat the Detroit Lions (8-6). Pittsburgh opens this matchup as 7-point dogs from Vegas oddsmakers. The over-under is set at 52. This report includes betting odds and our expert football picks for todays game.

Atlanta Falcons vs Arizona Cardinals Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/18/2025

The Arizona Cardinals (3-11) are welcoming the Atlanta Falcons (5-9) at State Farm Stadium on Sunday. Arizona opens this matchup as 2.5-point dogs from Vegas oddsmakers. The over-under has been set at 47.5. This matchup report includes odds, NFL betting predictions and a free pick against the spread.

Jacksonville Jaguars vs Denver Broncos Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/18/2025

The Denver Broncos (12-2) will take on the Jacksonville Jaguars (10-4) at Empower Field at Mile High on Sunday. Denver opens this game as 3-point favorites from Vegas oddsmakers. The total is set at 46.5. This matchup report includes Vegas odds and a free NFL pick for tonight.

Minnesota Vikings vs New York Giants Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/18/2025

MetLife Stadium is the site where the New York Giants (2-12) will try to beat the Minnesota Vikings (6-8) on Sunday. Minnesota opens this game as 3-point favorites. The over-under is set at 43.5. This matchup report has your NFL football pick of the day as well as NFL football odds for the game.

Tampa Bay Buccaneers vs Carolina Panthers Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/18/2025

Bank of America Stadium is the location where the Carolina Panthers (7-7) will attempt to defeat the Tampa Bay Buccaneers (7-7) on Sunday. Tampa Bay is 3-point favorites from Vegas oddsmakers. The over-under is set at 45.5. This report has odds and your NFL football predictions for todays game against the spread.

Green Bay Packers vs Chicago Bears Prediction, 12/20/2025 NFL Picks, Best Bets & Odds Week 16
by Guy Bruhn - 12/18/2025

The Green Bay Packers (9-4) are traveling to Soldier Field on Saturday where they will attempt to defeat the Chicago Bears (10-4). Green Bay opens this game as 1-point favorites from Vegas oddsmakers. The over-under is set at 46.5. This report includes betting predictions and our expert NFL picks for todays game.

Cincinnati Bengals vs Miami Dolphins Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/18/2025

Hard Rock Stadium is the location where the Miami Dolphins (6-8) will attempt to defeat the Cincinnati Bengals (4-10) on Sunday. Cincinnati opens this matchup as 4.5-point favorites from Vegas oddsmakers. The total is set at 47.5. This matchup report includes Vegas odds and a free NFL pick for tonight.

New York Jets vs New Orleans Saints Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

The New York Jets (3-11) are on their way to Caesars Superdome on Sunday where they will go up against the New Orleans Saints (4-10). New York opens as 4.5-point underdogs. The over-under has been set at 40.5. This matchup report has Vegas lines and an expert NFL football pick for your daily winner.

Buffalo Bills vs Cleveland Browns Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Parlays Pundit - 12/18/2025

Huntington Bank Field is the location where the Cleveland Browns (3-11) will take on the Buffalo Bills (10-4) on Sunday. Cleveland opens this matchup as 10-point underdogs from Vegas oddsmakers. The total is set at 42. We have included an expert NFL pick and parlay for todays game against the spread.

Kansas City Chiefs vs Tennessee Titans Prediction, 12/21/2025 NFL Picks, Best Bets & Odds Week 16
by Josh Schonwald - 12/18/2025

Nissan Stadium is the location where the Tennessee Titans (2-12) will meet the Kansas City Chiefs (6-8) on Sunday. Kansas City is 3.5-point favorites. The over-under is set at 37.5. This games report has current odds, betting predictions, and free picks against the spread.

San Francisco 49ers vs Indianapolis Colts Prediction, 12/22/2025 NFL Picks, Best Bets & Odds Week 16
by Tony Sink - 12/18/2025

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday. Indianapolis is 6-point dogs from Vegas oddsmakers. The total is set at 46.5. This matchup report includes odds, betting predictions and a free pick against the spread.