Free College Football Picks: Today's Expert Picks Against the Spread, College Football Best Bets, Predictions and Parlays.

UCLA Bruins vs Northwestern Wildcats Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

Martin Stadium is where the Northwestern Wildcats (1-2) will take on the UCLA Bruins (0-3) on Saturday, September 27, 2025. UCLA opens this contest as 6.5-point underdogs. The betting total is set at 45. This matchup report includes Vegas odds and a free college football prediction for tonight.

Memphis Tigers vs Florida Atlantic Owls Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Memphis Tigers (4-0) are hitting the road to Flagler Credit Union Stadium on Saturday, September 27, 2025 where they will compete against the Florida Atlantic Owls (1-2). Florida Atlantic is 14.0-point dogs. The over/under is set at 61.5. This matchup report includes betting lines and our NCAA football pick of the day for this game.

Arkansas State Red Wolves vs UL Monroe Warhawks Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Arkansas State Red Wolves (1-3) are hitting the road to Malone Stadium on Saturday, September 27, 2025 where they will attempt to beat the UL Monroe Warhawks (2-1). Arkansas State opens this game as 2.0-point underdogs from Vegas oddsmakers. The total is set at 55.5. This matchup report includes odds, NCAA football betting predictions and a free pick against the spread.

San Jose State Spartans vs Stanford Cardinal Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Stanford Cardinal (1-3) will compete against the San Jose State Spartans (1-2) at Stanford Stadium on Saturday, September 27, 2025. Stanford opens this game as 2.5-point favorites. The total comes in at 49.5. This matchup report includes Vegas odds and a free NCAA football pick for tonight.

California Golden Bears vs Boston College Eagles Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Boston College Eagles (1-2) will compete against the California Golden Bears (3-1) at Alumni Stadium on Saturday, September 27, 2025. Boston College opens as 6.5-point favorites. The over/under has been set at 51. This games report has current odds, betting predictions, and free picks against the spread.

Jacksonville State Gamecocks vs Southern Miss Golden Eagles Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

M. M. Roberts StadiumM. M. Roberts Stadium is the location where the Southern Miss Golden Eagles (2-2) will take on the Jacksonville State Gamecocks (2-2) on Saturday, September 27, 2025. Southern Miss opens this game as 5.0-point favorites. The over/under is set at 57. This matchup report includes odds, betting predictions and a free pick against the spread.

Louisiana Tech Bulldogs vs UTEP Miners Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Louisiana Tech Bulldogs (3-1) are traveling to Sun Bowl on Saturday, September 27, 2025 where they will attempt to beat the UTEP Miners (1-3). UTEP opens this game as 4.0-point underdogs from oddsmakers. The over/under is 48. This games report has current odds, betting predictions, and free picks against the spread.

Rutgers Scarlet Knights vs Minnesota Golden Gophers Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

Huntington Bank Stadium is the site where the Minnesota Golden Gophers (2-1) will meet the Rutgers Scarlet Knights (3-1) on Saturday, September 27, 2025. Minnesota opens this contest as 5.5-point favorites from Vegas oddsmakers. The total is 51. This matchup report includes odds, betting predictions and a free pick against the spread.

USC Trojans vs Illinois Fighting Illini Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The USC Trojans (4-0) are traveling to Memorial Stadium on Saturday, September 27, 2025 where they will compete against the Illinois Fighting Illini (3-1). Illinois opens this matchup as 7.0-point dogs. The total is set at 59. This matchup report has Vegas lines and an expert college football football pick for your daily winner.

Auburn Tigers vs Texas A&M Aggies Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Auburn Tigers (3-1) are headed to Kyle Field on Saturday, September 27, 2025 where they will attempt to defeat the Texas A&M Aggies (3-0). Auburn opens as 6.0-point dogs. The over/under has been set at 52.5. This game report has an NCAA football pick, betting odds, and predictions for tonights key matchup.

Tennessee Volunteers vs Mississippi State Bulldogs Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

Davis Wade Stadium is where the Mississippi State Bulldogs (4-0) will attempt to defeat the Tennessee Volunteers (3-1) on Saturday, September 27, 2025. Mississippi State opens as 7.5-point dogs. The over/under is 62. This report includes betting odds and our expert football picks for todays game.

Ohio State Buckeyes vs Washington Huskies Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

Husky Stadium is where the Washington Huskies (3-0) will take on the Ohio State Buckeyes (3-0) on Saturday, September 27, 2025. Ohio State opens this contest as 8.0-point favorites from Vegas oddsmakers. The betting total is set at 52.5. This matchup report includes Vegas odds and a free college football prediction for tonight.

Georgia Tech Yellow Jackets vs Wake Forest Demon Deacons Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Georgia Tech Yellow Jackets (4-0) are en route to Allegacy Federal Credit Union Stadium on Saturday, September 27, 2025 where they will try to beat the Wake Forest Demon Deacons (2-1). Wake Forest opens this matchup as 14.5-point dogs. The total has been set at 53. This matchup report has your NCAA football pick of the day as well as college football odds for the game.

Baylor Bears vs Oklahoma State Cowboys Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Oklahoma State Cowboys (1-2) will try to defeat the Baylor Bears (2-2) at Boone Pickens Stadium on Saturday, September 27, 2025. Baylor opens this contest as 20.5-point favorites from Vegas oddsmakers. The betting total comes in at 59.5. This report includes betting odds and our expert football picks for todays game.

New Mexico State Aggies vs New Mexico Lobos Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The New Mexico State Aggies (2-1) are en route to University Stadium on Saturday, September 27, 2025 where they will meet the New Mexico Lobos (2-1). New Mexico opens as 14.0-point favorites. The over/under has been set at 55. This matchup report has Vegas lines and an expert college football football pick for your daily winner.

Notre Dame Fighting Irish vs Arkansas Razorbacks Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Notre Dame Fighting Irish (1-2) are traveling to Razorback Stadium on Saturday, September 27, 2025 where they will attempt to beat the Arkansas Razorbacks (2-2). Arkansas opens this matchup as 5.5-point dogs from Vegas oddsmakers. The betting total is set at 64.5. This matchup report has Vegas lines and an expert college football football pick for your daily winner.

Eastern Michigan Eagles vs Central Michigan Chippewas Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Eastern Michigan Eagles (1-3) are headed to Kelly/Shorts Stadium on Saturday, September 27, 2025 where they will take on the Central Michigan Chippewas (2-2). Eastern Michigan is 5.5-point dogs. The over/under is 53.5. This games report has current odds, betting predictions, and free picks against the spread.

Utah State Aggies vs Vanderbilt Commodores Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

FirstBank Stadium is the location where the Vanderbilt Commodores (4-0) will attempt to defeat the Utah State Aggies (3-1) on Saturday, September 27, 2025. Vanderbilt opens this matchup as 22.0-point favorites from oddsmakers. The over/under comes in at 59. This matchup report has your NCAA football pick of the day as well as college football odds for the game.

San Diego State Aztecs vs NIU Huskies Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The NIU Huskies (1-2) will try to beat the San Diego State Aztecs (2-1) at Huskie Stadium on Saturday, September 27, 2025. San Diego State opens this contest as 3.0-point favorites from Vegas oddsmakers. The total is set at 43. This report has odds and your NCAA football predictions for todays game against the spread.

MTSU Blue Raiders vs Kennesaw State Owls Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

Fifth Third Stadium is the location where the Kennesaw State Owls (2-2) will meet the MTSU Blue Raiders (1-3) on Saturday, September 27, 2025. Kennesaw State opens this contest as 8.5-point favorites from Vegas oddsmakers. The over/under comes in at 51. This game report has an NCAA football pick, betting odds, and predictions for tonights key matchup.

Alabama Crimson Tide vs Georgia Bulldogs Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Georgia Bulldogs (3-0) will try to beat the Alabama Crimson Tide (2-1) at Sanford Stadium on Saturday, September 27, 2025. Alabama opens this game as 3.0-point underdogs. The over/under is set at 53. This matchup report includes odds, NCAA football betting predictions and a free pick against the spread.

UMass Minutemen vs Missouri Tigers Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The UMass Minutemen (0-3) are traveling to Memorial Stadium on Saturday, September 27, 2025 where they will try to defeat the Missouri Tigers (4-0). UMass opens this matchup as 43.5-point dogs. The over/under is 56.5. This matchup report includes Vegas odds and a free NCAA football pick for tonight.

Connecticut Huskies vs Buffalo Bulls Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Buffalo Bulls (2-2) welcome the Connecticut Huskies (2-2) at UB Stadium on Saturday, September 27, 2025. Connecticut opens as 2.5-point favorites. The over/under is 51. This matchup report includes Vegas odds and a free NCAA football pick for tonight.

Houston Cougars vs Oregon State Beavers Prediction, 9/26/2025 College Football Picks, Best Bets & Odds
by Parlays Pundit - 9/23/2025

The Oregon State Beavers (0-4) are welcoming the Houston Cougars (3-0) at Reser Stadium on Friday, September 26, 2025. Oregon State opens as 12.5-point dogs. The over/under is 48. We have included an expert college football pick and parlay for todays game against the spread.

Army Black Knights vs East Carolina Pirates Prediction, 9/25/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Army Black Knights (1-2) are hitting the road to Dowdy-Ficklen Stadium on Thursday, September 25, 2025 where they will try to beat the East Carolina Pirates (2-2). East Carolina opens this matchup as 5.0-point favorites from oddsmakers. The over/under has been set at 52.5. This matchup report includes college football odds, predictions, and a free pick against the spread.

Bowling Green Falcons vs Ohio Bobcats Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Bowling Green Falcons (2-2) are headed to Peden Stadium on Saturday, September 27, 2025 where they will try to defeat the Ohio Bobcats (2-2). Bowling Green opens as 10.5-point dogs from Vegas oddsmakers. The over/under has been set at 51. This matchup report includes Vegas odds and a free college football prediction for tonight.

Rice Owls vs Navy Midshipmen Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Rice Owls (3-1) are hitting the road to Navy-Marine Corps Memorial Stadium on Saturday, September 27, 2025 where they will try to beat the Navy Midshipmen (3-0). Navy opens this contest as 14.5-point favorites from Vegas oddsmakers. The over/under is set at 45.5. This report has odds and your NCAA football predictions for todays game against the spread.

Marshall Thundering Herd vs Louisiana Ragin' Cajuns Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

Cajun Field is the site where the Louisiana Ragin' Cajuns (1-3) will attempt to defeat the Marshall Thundering Herd (2-2) on Saturday, September 27, 2025. Marshall is 1.0-point underdogs. The over/under comes in at 46.5. This matchup report includes Vegas odds and a free NCAA football pick for tonight.

Akron Zips vs Toledo Rockets Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Toledo Rockets (2-2) welcome the Akron Zips (1-3) at Glass Bowl on Saturday, September 27, 2025. Toledo opens this game as 20.5-point favorites. The total comes in at 48.5. This matchup report includes odds, betting predictions and a free pick against the spread.

Utah Utes vs West Virginia Mountaineers Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Utah Utes (3-1) are headed to Milan Puskar Stadium on Saturday, September 27, 2025 where they will compete against the West Virginia Mountaineers (2-2). Utah opens this game as 9.5-point favorites. The total is 49. This matchup report includes betting lines and our NCAA football pick of the day for this game.

LSU Tigers vs Ole Miss Rebels Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The LSU Tigers (4-0) are headed to Vaught-Hemingway Stadium on Saturday, September 27, 2025 where they will go up against the Ole Miss Rebels (4-0). LSU opens this contest as 2.5-point dogs. The total is 55.5. This games report has current odds, betting predictions, and free picks against the spread.

TCU Horned Frogs vs Arizona State Sun Devils Prediction, 9/26/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

Mountain America Stadium is the location where the Arizona State Sun Devils (3-1) will take on the TCU Horned Frogs (3-0) on Friday, September 26, 2025. TCU opens this contest as 2.5-point underdogs from oddsmakers. The total is set at 54.5. This matchup report includes football betting lines and our pick of the day for this game.

Arizona Wildcats vs Iowa State Cyclones Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

Jack Trice Stadium is where the Iowa State Cyclones (4-0) will take on the Arizona Wildcats (3-0) on Saturday, September 27, 2025. Iowa State is 6.5-point favorites. The total is set at 50. This matchup report includes odds, NCAA football betting predictions and a free pick against the spread.

Liberty Flames vs Old Dominion Monarchs Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Liberty Flames (1-3) are on their way to S.B. Ballard Stadium on Saturday, September 27, 2025 where they will go up against the Old Dominion Monarchs (2-1). Liberty opens as 16.0-point dogs from Vegas oddsmakers. The over/under is 52. This matchup report includes Vegas odds and a free college football prediction for tonight.

UCF Knights vs Kansas State Wildcats Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Kansas State Wildcats (1-3) will go up against the UCF Knights (3-0) at Bill Snyder Family Stadium on Saturday, September 27, 2025. Kansas State opens this game as 6.0-point favorites from Vegas oddsmakers. The total has been set at 50.5. This report has odds and your NCAA football predictions for todays game against the spread.

South Alabama Jaguars vs North Texas Mean Green Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The North Texas Mean Green (4-0) will go up against the South Alabama Jaguars (1-3) at DATCU Stadium on Saturday, September 27, 2025. South Alabama opens this contest as 13.0-point dogs. The total is set at 63.5. This report includes betting odds and our expert football picks for todays game.

Appalachian State Mountaineers vs Boise State Broncos Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Boise State Broncos (2-1) will try to defeat the Appalachian State Mountaineers (2-1) at Albertsons Stadium on Saturday, September 27, 2025. Appalachian State opens this contest as 17.0-point underdogs from oddsmakers. The total comes in at 60.5. This matchup report includes betting lines and our NCAA football pick of the day for this game.

Indiana Hoosiers vs Iowa Hawkeyes Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Iowa Hawkeyes (3-1) welcome the Indiana Hoosiers (4-0) at Kinnick Stadium on Saturday, September 27, 2025. Indiana is 7.0-point favorites. The betting total comes in at 48. This matchup report includes Vegas odds and a free NCAA football pick for tonight.

Cincinnati Bearcats vs Kansas Jayhawks Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Josh Schonwald - 9/23/2025

The Cincinnati Bearcats (2-1) are traveling to David Booth Kansas Memorial Stadium on Saturday, September 27, 2025 where they will try to beat the Kansas Jayhawks (3-1). Kansas opens as 6.5-point favorites. The total is 55.5. This matchup report includes odds, NCAA football betting predictions and a free pick against the spread.

Georgia Southern Eagles vs James Madison Dukes Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

The Georgia Southern Eagles (2-2) are traveling to Bridgeforth Stadium on Saturday, September 27, 2025 where they will play the James Madison Dukes (2-1). James Madison is 17.0-point favorites. The total comes in at 55. This game report has an NCAA football pick, betting odds, and predictions for tonights key matchup.

Florida State Seminoles vs Virginia Cavaliers Prediction, 9/26/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

Scott Stadium is the location where the Virginia Cavaliers (3-1) will attempt to defeat the Florida State Seminoles (3-0) on Friday, September 26, 2025. Virginia opens this matchup as 7.5-point underdogs from oddsmakers. The betting total comes in at 58. This report includes betting predictions and our expert college football picks for todays game.

BYU Cougars vs Colorado Buffaloes Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Colorado Buffaloes (2-2) will play the BYU Cougars (3-0) at Folsom Field on Saturday, September 27, 2025. BYU opens this game as 6.5-point favorites. The over/under is set at 47. This matchup report includes betting lines and our NCAA football pick of the day for this game.

Hawaii Warriors vs Air Force Falcons Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

The Hawaii Warriors (3-2) are hitting the road to Falcon Stadium on Saturday, September 27, 2025 where they will try to defeat the Air Force Falcons (1-2). Hawaii is 6.0-point underdogs. The over/under has been set at 53. This matchup report has your NCAA football pick of the day as well as college football odds for the game.

Washington State Cougars vs Colorado State Rams Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Tony Sink - 9/23/2025

Canvas Stadium is the location where the Colorado State Rams (1-2) will play the Washington State Cougars (2-2) on Saturday, September 27, 2025. Colorado State opens this game as 4.5-point favorites. The total has been set at 50.5. This report includes betting odds and our expert football picks for todays game.

Kentucky Wildcats vs South Carolina Gamecocks Prediction, 9/27/2025 College Football Picks, Best Bets & Odds
by Guy Bruhn - 9/23/2025

Williams-Brice Stadium is the site where the South Carolina Gamecocks (2-2) will play the Kentucky Wildcats (2-1) on Saturday, September 27, 2025. Kentucky is 6.5-point underdogs from oddsmakers. The total has been set at 47. This matchup report has your NCAA football pick of the day as well as college football odds for the game.